NITHIAMIDE

First approved in 1956

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H5N3O3S
Molecular Weight	187.177
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC1=NC=C(S1)[N+]([O-])=O

InChI

InChIKey=UJRRDDHEMZLWFI-UHFFFAOYSA-N

InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)

HIDE SMILES / InChI

Molecular Formula	C5H5N3O3S
Molecular Weight	187.177
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13446429

Aminitrozole (Tritheon), also known as nithiamide, for some years has been successfully used in medicated feeds in the prevention of enterohepatitis (blackhead disease) in turkeys. Besides, this drug was studied in human for the treatment of trichomoniasis. Sixteen patients with vaginal trichomoniasis have been treated with Tritheon tablets. As a result, in all the thirteen patients followed, T. vaginitis was recovered after therapy. No untoward side-effects were noted, but the clinical results were uniformly bad.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Vaginal trichomoniasis 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13446429	Curative		Not Provided 511	Tritheon Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY521663	https://www.001chemical.com/chem/140-40-9
3B Scientific (Wuhan) Corp	3B3-013492	http://www.3bsc.com/index/pro_info.php?id=35992
AA Blocks	AA003B34	https://www.aablocks.com/goods/Goods/detail?id=AA003B34
Aaron Chemicals	AR003BUW	http://www.aaronchem.com/140-40-9
abcr GmbH	AB177433	http://www.abcr.com/shop/en/AB177433
AbMole Bioscience	M5816	http://www.abmole.com/products/nithiamide.html
Acadechem	ACDS-034076	http://www.acadechemical.com/product/108775
Accela ChemBio Inc	SY038271	http://www.accelachem.com/cn/search.html?keyword=SY038271&attname=GoodsCode
Achemica	ACMC-1BZ4S	http://www.achemica.com/prodinfo/?id=75831
Achemo Scientific Limited	AC-22303	http://www.achemo.com/search/?Keyword= 140-40-9
AHH Chemical co.,ltd	MT-32615	http://www.ahhchemical.com/product/MT-32615.html
AK Scientific, Inc. (AKSCI)	R054	http://www.aksci.com/item_detail.php?cat=R054
Alfa Aesar	L01356	https://www.alfa.com/en/catalog/L01356/
Ambinter	Amb20620170	http://www.ambinter.com/reference/20620170
Ambinter	Amb2502486	http://www.ambinter.com/reference/2502486
Angel Pharmatech	AG307897	http://www.angelpharmatech.com/140-40-9.html
Angene	AGN-PC-0JK8Q9	http://www.angenechemical.com/productshow/AGN-PC-0JK8Q9.html
Anward	ANW-20564	http://www.anward.com/pro_result/4992
ApexBio Technology	B1800	http://www.apexbt.com/nithiamide.html
Ark Pharm	AK-59142	http://www.arkpharminc.com/products/140-40-9.html
Aurora Fine Chemicals LLC	A13.126.284	http://online.aurorafinechemicals.com/info?ID=A13.126.284
Avantor Inc	TCA0689-005G	https://us.vwr.com/store/product/10047843/2-acetamido-5-nitrothiazole-98-0-by-hplc-titration-analysis
Avantor Inc	TCA0689-1G	https://us.vwr.com/store/product/10047843/2-acetamido-5-nitrothiazole-98-0-by-hplc-titration-analysis
BioCrick	BCC4687	http://www.biocrick.com/Nithiamide-BCC4687.html
BioSynth	J-007387	https://www.biosynth.com/en/products/all-products/products/J-007387.html
BLD Pharm	BD2687	http://www.bldpharm.com/products/140-40-9.html
Chem Scene	CS-4486	http://www.chemscene.com/140-40-9.html
Chemspace	CSSB00000024997	https://chem-space.com/CSSB00000024997
Creasyn Finechem	627	http://www.creasyn.com/product-id-735.html
CSNpharm	CSN13711	https://www.csnpharm.com/products/nithiamide.html
Debye Scientific	DB-000132	http://www.debyesci.com/DB-000132.html
eNovation Chemicals	D387861	https://enovationchem.com/ProductDetails.asp?ProductID=D387861
eNovation Chemicals	D914259	https://www.enovationchem.com/ProductDetails.asp?ProductID=D914259
eNovation Chemicals	Y1044219	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1044219
Finetech	FT-0622274	http://www.finetechnology-ind.com/prod/detail/pub/140-40-9.html
Lab Network	LN00008539	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00008539
LGC Standards	DRE-C10012500	https://www.lgcstandards.com/US/en/p/DRE-C10012500
LGC Standards	LGCFOR1745.00	https://www.lgcstandards.com/US/en/p/LGCFOR1745.00
mcule	MCULE-2051874336	https://mcule.com/MCULE-2051874336/
MedChem Express	HY-B0992	https://www.medchemexpress.com/Nithiamide.html
Molcore	MC521663	https://www.molcore.com/product/140-40-9
MuseChem	A001007	https://www.musechem.com/product/A001007.html
Oakwood	223945	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=104944&ExtHyperLink=1
Otava	4435303	https://search.otavachemicals.com/#!/search?query=4435303&type=code&base=dbb
Sigma-Aldrich	33978_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/33978?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	S540846_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/s540846
Sinfoo Biotech	S018419	http://www.sinfoobiotech.com/product/1021817
Smolecule	S537271	http://www.smolecule.com/products/s537271
TCI (Tokyo Chemical Industry)	A0689	http://www.tcichemicals.com/eshop/en/us/commodity/A0689/index.html
THE BioTek	bt-277168	https://www.thebiotek.com/product/inhibitors/bt-277168
Vesino Industrial Co Ltd	VT10036	http://www.vsnchem.com/goto/product/49578/
VladaChem	VL265030-1G	https://www.vladachem.com/product.php?products=140-40-9

PubMed

Title	Date	PubMed
A swine dysentery model for evaluation of drug prophylaxis: efficacy of various drugs in the control of swine dysentery.	1981-01	7224318
Treatment of vaginal trichomoniasis with aminitrozole and trichomycin given orally.	1960	13844789
[Value of oral aminitrozole in progress of treatment of Trichomonas vaginitis].	1958-07-10	13585930
Treatment of vaginal trichomoniasis with 2-acetylamino-5-nitrothiazole (aminitrozole) given orally.	1957-06	13446429
Oral treatment of trichomonas vaginitis with aminitrozole.	1957-05-18	13426568

Sample Use Guides

In Vivo Use Guide

Aminitrozole (Tritheon) was given orally in 100 mg. pink-coated tablets three or four times a day for 6 to 14 days.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:55:39 GMT 2025` Edited by `admin` on `Mon Mar 31 17:55:39 GMT 2025`
Record UNII	9CBM60191Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMINITROZOLE

Preferred Name

English

NITHIAMIDE

Official Name

English

AMINITROZOLE [MI]

Common Name

English

NITHIAMIDE [USAN]

Common Name

English

2-ACETAMIDO-5-NITROTHIAZOLE

Common Name

English

N-(5-Nitro-2-thiazolyl)acetamide

Systematic Name

English

NSC-31539

Code

English

Aminitrozole [WHO-DD]

Common Name

English

CL-5279

Code

English

NSC-45914

Code

English

CL 5,279

Code

English

aminitrozole [INN]

Common Name

English

ACETAMIDE, N-(5-NITRO-2-THIAZOLYL)-

Systematic Name

English

ACINITRAZOLE

Common Name

English

AMINITROZOLE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C254