CHLORMERODRIN

US Previously Marketed

First approved in 1952

Details

Stereochemistry	RACEMIC
Molecular Formula	C5H11HgN2O2.Cl
Molecular Weight	367.2
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].COC(C[Hg+])CNC(N)=O

InChI

InChIKey=BJFGVYCULWBXKF-UHFFFAOYSA-M

InChI=1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C5H11HgN2O2
Molecular Weight	331.74
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68002717 | http://www.hmdb.ca/metabolites/HMDB0014674

CHLORMERODRIN, an isourea derivative, is an organomercury compound that was previously used as a diuretic. Its radiolabelled (197Hg, 203Hg) forms were used as diagnostics in renal imaging and brain scans.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Congestive heart failure 54 Sources: https://www.drugbank.ca/drugs/DB00534 https://www.ncbi.nlm.nih.gov/pubmed/13340564	Palliative		Approved 8429	Neohydrin Approved Use Diuretic, for the treatment of edema and congestive heart failure Launch Date -5.6808001E11

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:59445	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:59445
eMolecules	29571	https://www.emolecules.com/cgi-bin/more?vid=29571

PubMed

Title	Date	PubMed
Chlormerodrin: clinical effectiveness and absence of toxicity in congestive heart failure; report of a four-year study.	1959 Apr 4	13629153
EFFECTS OF CHLORMERODRIN, P-CHLOROMERCURIBENZOATE AND DICHLORPHENAMIDE ON RENAL SODIUM REABSORPTION AND OXYGEN CONSUMPTION.	1964	14263631
COMPARATIVE STUDIES ON MERCURATED 1-, 3-, AND 5- ALLYLHYDANTOINS AND CHLORMERODRIN.	1964 Jun 1	14191075

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:59:16 UTC 2023` Edited by `admin` on `Fri Dec 15 14:59:16 UTC 2023`
Record UNII	99T5TWO621
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORMERODRIN

Official Name

English

Chlormerodrin [WHO-DD]

Common Name

English

CHLORMERODRIN [MI]

Common Name

English

(3-(CHLOROMERCURI)-2-METHOXYPROPYL))UREA

Common Name

English

NSC-19911

Code

English

NEOHYDRIN

Brand Name

English

MERCLORAN

Brand Name

English

chlormerodrin [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C448