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Details

Stereochemistry ACHIRAL
Molecular Formula C14H15N2O
Molecular Weight 227.2822
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of ENISAMIUM

SMILES

C[n+]1ccc(cc1)C(=[OH+])[N-]Cc2ccccc2

InChI

InChIKey=QOEJDHLJOKRPJG-UHFFFAOYSA-O
InChI=1S/C14H14N2O/c1-16-9-7-13(8-10-16)14(17)15-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3/p+1

HIDE SMILES / InChI

Molecular Formula C14H15N2O
Molecular Weight 227.2822
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/29324660

Enisamium (4-(benzylcarbamoyl)-1-methylpyridinium iodide) is an isonicotinic acid derivative, that used as an antiviral agent in Russia. Enisamium suppresses the effect of influenza viruses and other pathogens of acute respiratory viral infections due to a direct inhibitory effect on the penetration of viruses through the cell membrane. Enisamium has interferonogenic properties, promotes an increase in the concentration of endogenous interferon (interferon alfa and gamma) in blood plasma by 3-4 times.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
In Vitro Bioavailability Study of an Antiviral Compound Enisamium Iodide.
2018 Jan 11
Patents

Patents

Sample Use Guides

0.5 g 3 times a day. The maximum single dose is 1 g, daily - 2 g. Treatment begins when the first signs of the disease appear. The recommended course of treatment is 5 to 7 days.
Route of Administration: Oral
MatTeks’s EpiAirway System (MatTek, Ashland, MA) differentiated normal human-derived bronchial epithelial cells (NHBE) were used for the study. The cells from a single donor were used for assay consistency. The apical surface of the cells was exposed to a humidified 95% air/5% CO2 environment and the basolateral medium changed and mucin washed every 24-48 hours. NHBE cells were inoculated with influenza A viruses by exposure of the apical side to influenza virus. After a 1-hour incubation, the viral inoculum was removed from the cells, the apical side of the cells washed with Phosphate Buffered Saline (PBS). For the positive control, oseltamivir carboxylate, NHBE cultures were exposed on the basal side to oseltamivir for 60 minutes, prior to viral inoculation. Enisamium (40-1000mkM) or control media was added to the in the basal media compartment of the NHBE culture system prior to or post inoculation and incubated for the indicated duration of the experiment.
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:50:40 UTC 2021
Edited
by admin
on Sat Jun 26 04:50:40 UTC 2021
Record UNII
99SS65Q7OY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ENISAMIUM
Common Name English
PYRIDINIUM, 1-METHYL-4-(((PHENYLMETHYL)AMINO)CARBONYL)-
Systematic Name English
4-(BENZYLCARBAMOYL)-1-METHYLPYRIDIN-1-IUM
Systematic Name English
ENISAMIUM ION
Common Name English
ENISAMIUM CATION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C281
Created by admin on Sat Jun 26 04:50:40 UTC 2021 , Edited by admin on Sat Jun 26 04:50:40 UTC 2021
Code System Code Type Description
EPA CompTox
116533-18-7
Created by admin on Sat Jun 26 04:50:40 UTC 2021 , Edited by admin on Sat Jun 26 04:50:40 UTC 2021
PRIMARY
FDA UNII
99SS65Q7OY
Created by admin on Sat Jun 26 04:50:40 UTC 2021 , Edited by admin on Sat Jun 26 04:50:40 UTC 2021
PRIMARY
NCI_THESAURUS
C87663
Created by admin on Sat Jun 26 04:50:40 UTC 2021 , Edited by admin on Sat Jun 26 04:50:40 UTC 2021
PRIMARY
PUBCHEM
2132298
Created by admin on Sat Jun 26 04:50:40 UTC 2021 , Edited by admin on Sat Jun 26 04:50:40 UTC 2021
PRIMARY
CAS
116533-18-7
Created by admin on Sat Jun 26 04:50:40 UTC 2021 , Edited by admin on Sat Jun 26 04:50:40 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY