| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H20Cl2N2O3S |
| Molecular Weight | 487.398 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(C=C1)S(=O)(=O)CCN2C3=C(C=C(Cl)C=C3)C(=NCC2=O)C4=C(Cl)C=CC=C4
InChI
InChIKey=FFZOBTGTWSRRMB-UHFFFAOYSA-N
InChI=1S/C24H20Cl2N2O3S/c1-16-6-9-18(10-7-16)32(30,31)13-12-28-22-11-8-17(25)14-20(22)24(27-15-23(28)29)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3
| Molecular Formula | C24H20Cl2N2O3S |
| Molecular Weight | 487.398 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Tolufazepam is a 1-alkylsulfonylaryl-1,4-benzodiazepine derivative. It exhibited a competitive antagonism of 3H-diazepam binding in the cerebellum, cerebrum and submaxillary gland. Tolufazepam showed anticonvulsant and anxiolytic activity in animal models – it was very potent in preventing convulsions elicited by pentylenetetrazol. This anticonvulsant action was suppressed by previous administration of Ro 15-1788. Tolufazepam was also active in inhibiting suppressive behavior in the test of Vogel.
