TOLUFAZEPAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H20Cl2N2O3S
Molecular Weight	487.398
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(C=C1)S(=O)(=O)CCN2C3=C(C=C(Cl)C=C3)C(=NCC2=O)C4=C(Cl)C=CC=C4

InChI

InChIKey=FFZOBTGTWSRRMB-UHFFFAOYSA-N

InChI=1S/C24H20Cl2N2O3S/c1-16-6-9-18(10-7-16)32(30,31)13-12-28-22-11-8-17(25)14-20(22)24(27-15-23(28)29)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3

HIDE SMILES / InChI

Molecular Formula	C24H20Cl2N2O3S
Molecular Weight	487.398
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2901826 | DOI: 10.1016/S0065-7743(08)60524-2 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1219, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Tolufazepam is a 1-alkylsulfonylaryl-1,4-benzodiazepine derivative. It exhibited a competitive antagonism of 3H-diazepam binding in the cerebellum, cerebrum and submaxillary gland. Tolufazepam showed anticonvulsant and anxiolytic activity in animal models – it was very potent in preventing convulsions elicited by pentylenetetrazol. This anticonvulsant action was suppressed by previous administration of Ro 15-1788. Tolufazepam was also active in inhibiting suppressive behavior in the test of Vogel.

Approval Year

PubMed

Title	Date	PubMed
Pharmacological activity of novel alkylsulfonylaryl-1-substituted-1,4-benzodiazepine derivatives.	1988 May-Jun	2901826

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:54:54 GMT 2023` Edited by `admin` on `Fri Dec 15 15:54:54 GMT 2023`
Record UNII	98SR74X50D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TOLUFAZEPAM

Official Name

English

tolufazepam [INN]

Common Name

English

Tolufazepam [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1012