Mirvetuximab Soravtansine

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 22:49:02 GMT 2025` Edited by `admin` on `Mon Mar 31 22:49:02 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	MOUSE CHIMERIC
Sequence Type	COMPLETE
Record UNII	98DE7VN88D
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

mirvetuximab soravtansine [INN]

Preferred Name

English

Mirvetuximab Soravtansine

Official Name

English

Immunoglobulin G1-kappa, anti-(human folate receptor alpha (adult folatebending protein, folate receptor 1, KB cells FBP, ovarian tumor-associated antigen Mov18)); humanized mouse monoclonal antibody linked to an average of four molecules of maytansine a

Common Name

English

MIRVETUXIMAB SORAVTANSINE [USAN]

Common Name

English

IMGN-853

Code

English

Immunoglobulin G1, anti-(human folate receptor ?) (human-Mus musculus monoclonal M9346A heavy chain), disulfide with human-Mus musculus monoclonal M9346A light chain, dimer, tetraamide with N2'-[4-[(3-carboxy-3- sulfopropyl)dithio]-4-methyl-1-oxopentyl]-

Common Name

English

IMGN853

Code

English

Mirvetuximab soravtansine [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

435214

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

FDA ORPHAN DRUG

781620

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

Code System Code Type Description

ChEMBL

CHEMBL2109414

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

CAS

1453084-37-1

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

DRUG BANK

DB12489

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

FDA UNII

98DE7VN88D

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

EVMPD

SUB181124

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

DAILYMED

98DE7VN88D

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

RXCUI

2621548

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

USAN

BC-78

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

PUBCHEM

91810695

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

SMS_ID

100000166842

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

NCI_THESAURUS

C102566

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

INN

10176

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

ChEMBL

CHEMBL3545132

Created by admin on Mon Mar 31 22:49:02 GMT 2025 , Edited by admin on Mon Mar 31 22:49:02 GMT 2025

PRIMARY

From	To
1_22	1_96
1_145	1_201
1_221	3_218
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426
2_22	2_96
2_145	2_201
2_221	4_218
2_262	2_322
2_368	2_426
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					I9G3JZ25IH

FOLATE RECEPTOR ALPHA

TARGET->CONJUGATED TOXIN

Amount:

Mirvetuximab Soravtansine-GYNX

SUB_CONCEPT->SUBSTANCE

Amount:

Related Record Type Details


					98DE7VN88D

Mirvetuximab Soravtansine

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	K	Amount:	SORAVTANSINE-LYSINE	VIX9T64XBU

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL