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Details

Stereochemistry ACHIRAL
Molecular Formula C21H22F2N2O3S
Molecular Weight 420.4747
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENZENESULFONIC ACID, 2,6-DIFLUORO-, 1-METHYL-3-(1-METHYL-4-PIPERIDINYL)-1H-INDOL-5-YL ESTER

SMILES

CN1CCC(CC1)c2cn(C)c3ccc(cc23)OS(=O)(=O)c4c(cccc4F)F

InChI

InChIKey=LYHNZWIPSZUYDT-UHFFFAOYSA-N
InChI=1S/C21H22F2N2O3S/c1-24-10-8-14(9-11-24)17-13-25(2)20-7-6-15(12-16(17)20)28-29(26,27)21-18(22)4-3-5-19(21)23/h3-7,12-14H,8-11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C21H22F2N2O3S
Molecular Weight 420.4747
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SGS518 is a selective antagonist of the 5-Hydroxytryptamine-6 (5-HT6) serotonin receptor believed to act by enhancing transmission of chemicals in the brain. Prior preclinical evaluation of SGS518 has shown it to be effective in behavioral studies of learning and memory. Saegis is developing SGS518 in cooperation with Eli Lilly and Company as a treatment for Cognitive Impairment Associated with Schizophrenia (CIAS) with some support from The Stanley Medical Research Institute. SGS518 in the phase II of clinical trial. The objective of this Phase IIa study was to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of oral doses of SGS518 compared to placebo when given to schizophrenia patients stable on antipsychotic medication. SGS518 appears to be safe and well tolerated with preliminary evidence suggesting improvement in cognition using the BACS in patients with schizophrenia.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

Multiple doses of up to 240 mg of SGS518 administered once daily
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 08:29:33 UTC 2021
Edited
by admin
on Sat Jun 26 08:29:33 UTC 2021
Record UNII
97S8606IT3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BENZENESULFONIC ACID, 2,6-DIFLUORO-, 1-METHYL-3-(1-METHYL-4-PIPERIDINYL)-1H-INDOL-5-YL ESTER
Common Name English
Code System Code Type Description
PUBCHEM
6918827
Created by admin on Sat Jun 26 08:29:33 UTC 2021 , Edited by admin on Sat Jun 26 08:29:33 UTC 2021
PRIMARY
CAS
445441-26-9
Created by admin on Sat Jun 26 08:29:33 UTC 2021 , Edited by admin on Sat Jun 26 08:29:33 UTC 2021
PRIMARY
FDA UNII
97S8606IT3
Created by admin on Sat Jun 26 08:29:33 UTC 2021 , Edited by admin on Sat Jun 26 08:29:33 UTC 2021
PRIMARY
EPA CompTox
445441-26-9
Created by admin on Sat Jun 26 08:29:33 UTC 2021 , Edited by admin on Sat Jun 26 08:29:33 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR