SULFACHLORPYRAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H9ClN4O2S
Molecular Weight	284.722
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=C(Cl)N=C2

InChI

InChIKey=GDANWVKBBCWCIJ-UHFFFAOYSA-N

InChI=1S/C10H9ClN4O2S/c11-9-5-14-10(6-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)

HIDE SMILES / InChI

Molecular Formula	C10H9ClN4O2S
Molecular Weight	284.722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23682263 | https://www.jstage.jst.go.jp/article/jpsa1964/11/3/11_3_75/_pdf

Sulfachloropyrazine, a sulfonamide, was developed as a drug for poultry coccidiosis. Sulfachloropyrazine was found to be a therapeutic option for T. gondii infection in animals.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4805788 https://www.ncbi.nlm.nih.gov/pubmed/2583024 http://agris.fao.org/agris-search/search.do?recordID=PL8301030 http://www-staro.vef.unizg.hr/vetarhiv/papers/2013-83-2-9.pdf	Curative		Approved 8429	SULFATYF Approved Use Poultry coccidiosis
Toxoplasmosis 12 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23569838 https://www.ncbi.nlm.nih.gov/pubmed/23682263	Curative		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Effectiveness of sulfachlorpyrazine in coccidiosis of rabbits].	1973 Apr	4805788
[The compatibility of the new ionophore-coccidiostats with other chemotherapeutics in broilers].	1989 Oct	2583024
Comparative studies on the efficacy of sulphachlorpyrazine and toltrazuril for the treatment of caecal coccidiosis in chickens.	1995 Jun	7657461

Patents

Sample Use Guides

In Vivo Use Guide

chicken and turkey: 0.03% sulfachlorpyrazine solution as source of water for 3 days.

Route of Administration: Oral

In Vitro Use Guide

T. gondii tachyzoites were soaked in sulfachloropyrazine (250 mg/mL) for 2 h at 37 °C.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:44:32 GMT 2023` Edited by `admin` on `Fri Dec 15 19:44:32 GMT 2023`
Record UNII	96R84UZ2XA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFACHLORPYRAZINE

Common Name

English

BENZENESULFONAMIDE, 4-AMINO-N-(5-CHLORO-2-PYRAZINYL)-

Systematic Name

English

BENZENESULFONAMIDE, 4-AMINO-N-(5-CHLOROPYRAZINYL)-

Systematic Name

English

4-AMINO-N-(5-CHLOROPYRAZINYL)-BENZENESULFONAMIDE

Systematic Name

English

Code System Code Type Description

CAS

1672-91-9