Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H22BrF3N2O5S |
| Molecular Weight | 539.363 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(Br)=C(C=C1OC)S(=O)(=O)NC2=CC(O[C@@H]3CCN(C)C3)=C(C=C2)C(F)(F)F
InChI
InChIKey=BPOWQJYAMDEAFF-CYBMUJFWSA-N
InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1
| Molecular Formula | C20H22BrF3N2O5S |
| Molecular Weight | 539.363 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/22327329 | https://www.ncbi.nlm.nih.gov/pubmed/24340095
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/22327329 | https://www.ncbi.nlm.nih.gov/pubmed/24340095
SB-706375 is a potent, surmountable, reversible and selective mammalian urotensin-II receptor antagonist. In rats SB-706375 provoked a pronounced diuresis and natriuresis, accompanied by modest increases in effective renal blood flow and glomerular filtration rate.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. | 2005 Jul |
|
| Ontogeny of the renal urotensin II system in the rat. | 2012 Jun |
|
| The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat. | 2013 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:28:12 GMT 2023
by
admin
on
Sat Dec 16 14:28:12 GMT 2023
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| Record UNII |
96711H97SD
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| Record Status |
Validated (UNII)
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| Record Version |
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96711H97SD
Created by
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21023902
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733734-61-7
Created by
admin on Sat Dec 16 14:28:12 GMT 2023 , Edited by admin on Sat Dec 16 14:28:12 GMT 2023
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