Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.1729 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C[C@@H](N)C(O)=O
InChI
InChIKey=ROHFNLRQFUQHCH-RXMQYKEDSA-N
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.1729 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Uptake of [3H]L-serine in rat brain synaptosomal fractions. | 2003-09-05 |
|
| Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL). | 2003-09 |
|
| Effects of acute tryptophan depletion on executive function in healthy male volunteers. | 2003-08-04 |
|
| Dietary protein reduction in sheep and goats: different effects on L-alanine and L-leucine transport across the brush-border membrane of jejunal enterocytes. | 2003-08 |
|
| Diagnosis of maple syrup urine disease by determination of L-valine, L-isoleucine, L-leucine and L-phenylalanine in neonatal blood spots by gas chromatography-mass spectrometry. | 2003-07-25 |
|
| Manipulation of CD98 expression affects both trophoblast cell fusion and amino acid transport activity during syncytialization of human placental BeWo cells. | 2003-07-01 |
|
| Regulation of L-leucine transport in rat kidney by dexamethasone and triiodothyronine. | 2003-07 |
|
| Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. | 2003-06-05 |
|
| Regulatory effects of 5'-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets. | 2003-06 |
|
| Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme. | 2003-05-14 |
|
| High cell density cultivation of Brevibacterium linens and formation of proteinases and lipase. | 2003-05 |
|
| Transport of L-arginine and nitric oxide formation in human platelets. | 2003-05 |
|
| Functional and molecular characteristics of system L in human breast cancer cells. | 2003-04-01 |
|
| L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. | 2003-04-01 |
|
| Spinal gabapentin and antinociception: mechanisms of action. | 2003-04 |
|
| [Preparation and pharmaceutical properties of salcatonin dry powder inhalations]. | 2003-03 |
|
| A comparative study on the rectal aminopeptidase enzymatic activities of different species. | 2003-03 |
|
| Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells. | 2003-02-07 |
|
| Increased nitric oxide synthesis in uraemic platelets is dependent on L-arginine transport via system y(+)L. | 2003-02 |
|
| Noncovalent chiral domino effect on one-handed helix of nonapeptide containing a midpoint L-residue. | 2003-01-14 |
|
| Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. | 2003-01-06 |
|
| Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells. | 2003-01-01 |
|
| Kynurenate production by cultured human astrocytes. | 2003-01 |
|
| Proteolytic activity of a yeast cell wall lytic Arthrobacter species. | 2003 |
|
| Biochemical characterization of the soluble alkaline phosphatase isolated from the venomous snake W. aegyptia. | 2002-12 |
|
| Monitoring the structural consequences of Phe12-->D-Phe and Leu15-->Aib substitution in human/rat corticotropin releasing hormone. Implications for design of CRH antagonists. | 2002-12 |
|
| Kinetics of sequential metabolism from D-leucine to L-leucine via alpha-ketoisocaproic acid in rat. | 2002-12 |
|
| Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine. | 2002-11-29 |
|
| Protective effect of D-glucose, L-leucine and fetal calf serum against oxidative stress in neonatal pancreatic islets. | 2002-11-20 |
|
| Prediction of the bitterness of single, binary- and multiple-component amino acid solutions using a taste sensor. | 2002-11-06 |
|
| 19F NMR study of the leucine-specific binding protein of Escherichia coli: mutagenesis and assignment of the 5-fluorotryptophan-labeled residues. | 2002-11 |
|
| Synthesis and conformational analysis of small peptides containing 6-endo-BT(t)L scaffolds as reverse turn mimetics. | 2002-10-18 |
|
| The stimulus-secretion coupling of amino acid-induced insulin release. Insulinotropic action of L-alanine. | 2002-10-10 |
|
| Studies on the macroscopic protonation constants of some alpha-amino acids in ethanol-water mixtures. | 2002-10-01 |
|
| [Studies on the cytological function of the biomembrane and the neurons]. | 2002-10 |
|
| Cloning and characterization of an aromatic amino acid and leucine permease of Penicillium chrysogenum. | 2002-09-20 |
|
| Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid. | 2002-09-12 |
|
| A continuous 96-well plate spectrophotometric assay for branched-chain amino acid aminotransferases. | 2002-09-01 |
|
| Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes. | 2002-09-01 |
|
| The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. | 2002-08-21 |
|
| A study of L-leucine, L-phenylalanine and L-alanine transport in the perfused rat mammary gland: possible involvement of LAT1 and LAT2. | 2002-08-19 |
|
| Effects of epidermal growth factor on placental amino acids uptake in pregnant rats. | 2002-08 |
|
| Genetic and physiological analysis of branched-chain alcohols and isoamyl acetate production in Saccharomyces cerevisiae. | 2002-08 |
|
| Glial induction of blood-brain barrier-like L-system amino acid transport in the ECV304 cell line. | 2002-08 |
|
| Synthesis and asymmetric reducing performance of chitin/dihydronicotinamide conjugates having glycine or L-leucine spacer arms. | 2002-07-09 |
|
| Oral amino-acid provision does not affect muscle strength or size gains in older men. | 2002-07 |
|
| Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier. | 2002-06 |
|
| Tumor necrosis factor-alpha mediates inhibitory effect of lipopolysaccharide on L-leucine intestinal uptake. | 2002-06 |
|
| Synthesis and anti-Helicobacter pylori activity of pyloricidin derivatives II. The combination of amino acid residues in the dipeptidic moiety and its effect on the anti-Helicobacter pylori activity. | 2002-05 |
|
| [Enantioseparation of twelve pharmaceutical racemates with high performance capillary electrophoresis using L-leucine as chiral selector]. | 2001-03 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:41:29 GMT 2025
by
admin
on
Mon Mar 31 23:41:29 GMT 2025
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| Record UNII |
965COD96YA
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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77687
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328-38-1
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DTXSID6046347
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965COD96YA
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DB01746
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439524
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