Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C5H11NO2Se |
Molecular Weight | 196.11 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[Se]CC[C@H](N)C(O)=O
InChI
InChIKey=RJFAYQIBOAGBLC-BYPYZUCNSA-N
InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
Molecular Formula | C5H11NO2Se |
Molecular Weight | 196.11 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12656658 | https://examine.com/supplements/selenium
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12656658 | https://examine.com/supplements/selenium
L-isomer of selenomethionine (Se-met) is a major natural food-form of selenium, synthetic L-Se-met or enriched food sources thereof such as selenium yeast are appropriate supplemental forms of Se for humans; for animals, DL-Se-met is acceptable. Ingested Se-met is either metabolized directly to reactive forms of selenium or stored in place of methionine in body proteins. Se-met metabolism is closely linked to protein turnover. Selenium, which is nutritionally essential for humans, is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10867031 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Selenium (selenomethionine) Approved UseSelenium (selenomethionine) is a natural antioxidant that delays the oxidation of polyunsaturated fatty acids and preserves the elasticity of tissue. Selenium is required for the production of certain prostaglandins, which promote healthy blood flow. In synergy with vitamin E, selenium promotes healthy growth and fertility, and improves the function of certain energy producing cells. Selenium also provides support for the immune system |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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75Se-selenomethionine excretion in bile and pancreatic juice. | 1975 |
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[Method of analysis of regional dynamics of the pancreas with 75Se-selenomethionine]. | 1977 Apr |
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[Determination of the selenomethionine content in grain and human blood]. | 1997 Mar |
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Micronutrients in cancer chemoprevention. | 2002 |
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Selenomethionine induction of DNA repair response in human fibroblasts. | 2002 May 23 |
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Selenium and breast-feeding. | 2002 Nov |
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Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes. | 2003 Nov 1 |
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In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells. | 2003 Nov-Dec |
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Analysis of organoselenium compounds in human urine using active carbon and chemically modified silica sol-gel surface-assisted laser desorption/ionization high-resolution time-of-flight mass spectrometry. | 2004 Apr 1 |
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Comparative effects of 2 antioxidants, selenomethionine and epigallocatechin-gallate, on catabolic and anabolic gene expression of articular chondrocytes. | 2005 Oct |
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Selenium metabolites in human urine after ingestion of selenite, L-selenomethionine, or DL-selenomethionine: a quantitative case study by HPLC/ICPMS. | 2005 Sep |
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Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation. | 2006 Dec |
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Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity. | 2006 Jul 28 |
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Double-stranded RNA-dependent protein kinase (PKR) is a stress-responsive kinase that induces NFkappaB-mediated resistance against mercury cytotoxicity. | 2006 Mar 13 |
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Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice. | 2007 Apr |
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Selenomethionine induced transcriptional programs in human prostate cancer cells. | 2007 Feb |
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Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells. | 2008 |
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Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. | 2008 Nov |
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Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium. | 2010 Oct 1 |
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Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds. | 2011 Jul |
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Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation. | 2011 Mar |
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Attenuation of the cortisol response to stress in female rainbow trout chronically exposed to dietary selenomethionine. | 2011 Oct |
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Induction of oxidative stress by selenomethionine in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss). | 2012 Jun |
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Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes. | 2012 Sep |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12398336
10 or 50 uM selenomethionine protects against cadmium toxicity in cultured K-562 cells.
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 16:46:32 UTC 2023
by
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on
Fri Dec 15 16:46:32 UTC 2023
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Record UNII |
964MRK2PEL
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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DSLD |
2384 (Number of products:20)
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DSLD |
2033 (Number of products:7)
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NCI_THESAURUS |
C275
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EU-Orphan Drug |
EU/3/16/1782
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Code System | Code | Type | Description | ||
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SELENOMETHIONINE
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62621
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C2833
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CHEMBL113178
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D012645
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DTXSID8046824
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964MRK2PEL
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30021
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3544
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DB11142
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105024
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1611955
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964MRK2PEL
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3211-76-5
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100000128771
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SUB36255
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9644
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m9848
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3211-76-5
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760370
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Related Record | Type | Details | ||
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