JNJ-17029259

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H30N6O
Molecular Weight	442.556
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(N)C1=CC=C(C=C1)C2=NC(NC3=CC=C(CCN4CCOCC4)C=C3)=NC=C2C#N

InChI

InChIKey=MROGTPNQSHMKIG-UHFFFAOYSA-N

InChI=1S/C26H30N6O/c1-26(2,28)22-7-5-20(6-8-22)24-21(17-27)18-29-25(31-24)30-23-9-3-19(4-10-23)11-12-32-13-15-33-16-14-32/h3-10,18H,11-16,28H2,1-2H3,(H,29,30,31)

HIDE SMILES / InChI

Molecular Formula	C26H30N6O
Molecular Weight	442.556
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasound-mediated addition of MeLi-CeCl3 to a nitrile.	2008-02-01	18171079
A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models.	2004-09	15322256

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:11:58 GMT 2025` Edited by `admin` on `Mon Mar 31 22:11:58 GMT 2025`
Record UNII	95RGX89OQD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

JNJ-17029259

Common Name

English

5-PYRIMIDINECARBONITRILE, 4-(4-(1-AMINO-1-METHYLETHYL)PHENYL)-2-((4-(2-(4-MORPHOLINYL)ETHYL)PHENYL)AMINO)-

Preferred Name

English

Code System Code Type Description

CAS

314267-57-7

Created by admin on Mon Mar 31 22:11:58 GMT 2025 , Edited by admin on Mon Mar 31 22:11:58 GMT 2025

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FDA UNII

95RGX89OQD

Created by admin on Mon Mar 31 22:11:58 GMT 2025 , Edited by admin on Mon Mar 31 22:11:58 GMT 2025

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PUBCHEM

11464906

Created by admin on Mon Mar 31 22:11:58 GMT 2025 , Edited by admin on Mon Mar 31 22:11:58 GMT 2025

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Related Record Type Details


					95RGX89OQD

JNJ-17029259

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