AMPHOTALIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20N2O3
Molecular Weight	324.3737
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=CC=C(OCCCCCN2C(=O)C3=CC=CC=C3C2=O)C=C1

InChI

InChIKey=GIIGAFADHXYOPM-UHFFFAOYSA-N

InChI=1S/C19H20N2O3/c20-14-8-10-15(11-9-14)24-13-5-1-4-12-21-18(22)16-6-2-3-7-17(16)19(21)23/h2-3,6-11H,1,4-5,12-13,20H2

HIDE SMILES / InChI

Molecular Formula	C19H20N2O3
Molecular Weight	324.3737
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: (1967) Annual Reports in Medicinal Chemistry, v.2, page 139, retrieved from: https://books.google.ru/books?id=nnVxhG5GLXYC | https://www.drugfuture.com/chemdata/amphotalide.html | Burger, A. (1970) Medicinal chemistry, v.1, page 589, retrieved from: https://books.google.ru/books?id=zRBtAAAAMAAJ

Amphotalide is an anthelminthic drug. Antischistosomal agent. Amphotalide produced a definite therapeutic effect on S. haematobium infections but diminution of visual field was observed in several patients. The search was therefore continued for compounds devoid of retinal toxicity and more active than amphotalide in experimental animals.

Approval Year

Sample Use Guides

In Vivo Use Guide

In divided doses every 12 hours over a period of 5 or 6 days. Total amount - 250 mg per kg body weight

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:38:15 GMT 2025` Edited by `admin` on `Wed Apr 02 09:38:15 GMT 2025`
Record UNII	95818EH730
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMPHOTALIDE

Official Name

English

AMPHOTALIDE [MI]

Preferred Name

English

AMPHOTALIDE [MART.]

Common Name

English

N-(5-(P-AMINOPHENOXY)PENTYL)PHTHALIMIDE

Common Name

English

amphotalide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250