D-106669

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H18N6O
Molecular Weight	322.3644
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCNC(=O)NC1=CC=C2N=CC(NC3=CC=C(C)C=C3)=NC2=N1

InChI

InChIKey=RQBRFKKFZPOBFG-UHFFFAOYSA-N

InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24)

HIDE SMILES / InChI

Molecular Formula	C17H18N6O
Molecular Weight	322.3644
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21426073

D-106669 was investigated in frame of research program PI3K and MAPK inhibitors of AEterna Zentaris. D-106669 is a highly selective to class I of PI3K alpha (phosphatidylinositol 3-kinase) inhibitor.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
PI3-kinase p110-alpha subunit 41 Target ID: CHEMBL4005 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21426073	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
		252160393

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:41:17 GMT 2023` Edited by `admin` on `Sat Dec 16 09:41:17 GMT 2023`
Record UNII	9575Q08390
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

D-106669

Common Name

English

UREA, N-ETHYL-N'-(3-((4-METHYLPHENYL)AMINO)PYRIDO(2,3-B)PYRAZIN-6-YL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

16048654

Created by admin on Sat Dec 16 09:41:17 GMT 2023 , Edited by admin on Sat Dec 16 09:41:17 GMT 2023

PRIMARY

FDA UNII

9575Q08390

Created by admin on Sat Dec 16 09:41:17 GMT 2023 , Edited by admin on Sat Dec 16 09:41:17 GMT 2023

PRIMARY

CAS

938444-93-0

Created by admin on Sat Dec 16 09:41:17 GMT 2023 , Edited by admin on Sat Dec 16 09:41:17 GMT 2023

PRIMARY

EPA CompTox

DTXSID10239783

Created by admin on Sat Dec 16 09:41:17 GMT 2023 , Edited by admin on Sat Dec 16 09:41:17 GMT 2023

PRIMARY

Related Record Type Details


					9575Q08390

D-106669

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/21426073

Originator

Approval Year

Targets

Conditions

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21426073