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DORNASE ALFA
953A26OA1Y
US Approved Rx (1993)
First approved in 1993
General
Record Details
Names
16
Classification
13
Identifiers
16
Subunits
1
Disulfide Links
2
Glycosylation
2
Active Moiety
1
Characteristic Attributes
2
DORNASE ALFA
953A26OA1Y
US Approved Rx (1993)
First approved in 1993
General
Approval Year
1993
136
Record Details
Substance Class
Protein
Protein Sub Type
Sequence Type
COMPLETE
Record UNII
953A26OA1Y
Record Status
Validated (UNII)
Record Version
27
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Names
16
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entries
Name
Type
Language
Name
Type
Language
DORNASE ALFA
Official Name
English
DORNASE ALFA [PURPLE BOOK CDER]
Common Name
English
DORNASE ALPHA
Common Name
English
RECOMBINANT DEOXYRIBONUCLEASE (DNASE)
Common Name
English
Dornase alfa [WHO-DD]
Common Name
English
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4
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Classification
13
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Designated/Approved
ORPHAN DRUG
Designated/Approved
To reduce mucous viscosity and enable the clearance of airway secretions in patients with cystic fibrosis.
FDA ORPHAN DRUG
48090
Biological Agent
Pharmacologic Substance
[C1909]
Biological Agent
[C307]
Enzyme Replacement or Supplement Agent
NCI_THESAURUS
C29726
Endodeoxyribonucleases
Chemical Ingredients
[Chemical/Ingredient]
Enzymes and Coenzymes
[Chemical/Ingredient]
Enzymes
[Chemical/Ingredient]
Hydrolases
[Chemical/Ingredient]
Esterases
[Chemical/Ingredient]
Deoxyribonucleases
[Chemical/Ingredient]
Endodeoxyribonucleases
[Chemical/Ingredient]
Deoxyribonuclease I
[Chemical/Ingredient]
NDF-RT
N0000007767
Established Pharmacologic Class
Established Pharmacologic Class
[EPC]
Recombinant Human Deoxyribonuclease 1
[EPC]
NDF-RT
N0000175958
Designated
ORPHAN DRUG
Designated
Treatment of pancreatic cancer
FDA ORPHAN DRUG
851921
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Identifiers
16
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Code System
Code
Type
Description
Code System
Code
Type
Description
MERCK INDEX
m4177
PRIMARY
Merck Index
INN
7167
PRIMARY
DRUG BANK
DB00003
PRIMARY
ChEMBL
CHEMBL1201431
PRIMARY
SMS_ID
100000080786
PRIMARY
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Subunits
1
Subunit 0
>SUBUNIT_0
Disulfide Links
2
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From
To
From
To
1_173
1_209
1_101
1_104
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Glycosylation
2
Glycosylation Type
MAMMALIAN
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Glycosylation Link Type
Site
Glycosylation Link Type
Site
N
1_18
N
1_106
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
953A26OA1Y
DORNASE ALFA
ACTIVE MOIETY
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Characteristic Attributes
2
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Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Molecular Formula
CHEMICAL
ESTIMATED
C1321H2010O382N352S9
MOL_WEIGHT:NUMBER(CALCULATED)
CHEMICAL
ESTIMATED 29200 Da (average)
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