Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H21FN6O.CH4O3S |
Molecular Weight | 416.471 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(O)(=O)=O.F[C@H]1C[C@@H](C#N)N(C1)C(=O)CN[C@@H]2CC[C@H](CN3C=NC=N3)C2
InChI
InChIKey=IAWFHPXSNMKWIL-QVYXHAGSSA-N
InChI=1S/C15H21FN6O.CH4O3S/c16-12-4-14(5-17)22(8-12)15(23)6-19-13-2-1-11(3-13)7-21-10-18-9-20-21;1-5(2,3)4/h9-14,19H,1-4,6-8H2;1H3,(H,2,3,4)/t11-,12-,13+,14-;/m0./s1
Molecular Formula | C15H21FN6O |
Molecular Weight | 320.3652 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | CH4O3S |
Molecular Weight | 96.106 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Melogliptin (EMD 675992 or GRC 8200) is an orally bioavailable dipeptidyl peptidase IV (DPP IV) inhibitor. Melogliptin was undergoing phase II clinical trials at Glenmark Pharmaceuticals and Merck KGaA for the treatment of type 2 diabetes. The completed 12 week Phase IIb clinical trial in 494 patients with type 2 diabetes melogliptin improved glycemic control in patients with type 2 diabetes mellitus and exhibited excellent safety and tolerability profile.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P27487 Gene ID: 1803.0 Gene Symbol: DPP4 Target Organism: Homo sapiens (Human) Sources: https://newdrugapprovals.org/2015/12/11/melogliptin/ |
1.61 nM [IC50] |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:56:12 UTC 2023
by
admin
on
Fri Dec 15 16:56:12 UTC 2023
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Record UNII |
94YJM64V3O
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Record Status |
Validated (UNII)
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Record Version |
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-
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300000042470
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46241183
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869368-93-4
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ACTIVE MOIETY |