MELOGLIPTIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H21FN6O
Molecular Weight	320.3652
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

F[C@H]1C[C@@H](C#N)N(C1)C(=O)CN[C@@H]2CC[C@H](CN3C=NC=N3)C2

InChI

InChIKey=JSYGLDMGERSRPC-FQUUOJAGSA-N

InChI=1S/C15H21FN6O/c16-12-4-14(5-17)22(8-12)15(23)6-19-13-2-1-11(3-13)7-21-10-18-9-20-21/h9-14,19H,1-4,6-8H2/t11-,12-,13+,14-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C15H21FN6O
Molecular Weight	320.3652
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://newdrugapprovals.org/2015/12/11/melogliptin/ | https://adisinsight.springer.com/drugs/800021640 | https://www.biocompare.com/Life-Science-News/48978-Glenmark-s-Novel-Molecule-for-Diabetes-Melogliptin-to-Enter-Phase-III-Trials/

Melogliptin (EMD 675992 or GRC 8200) is an orally bioavailable dipeptidyl peptidase IV (DPP IV) inhibitor. Melogliptin was undergoing phase II clinical trials at Glenmark Pharmaceuticals and Merck KGaA for the treatment of type 2 diabetes. The completed 12 week Phase IIb clinical trial in 494 patients with type 2 diabetes melogliptin improved glycemic control in patients with type 2 diabetes mellitus and exhibited excellent safety and tolerability profile.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dipeptidyl peptidase 4 8 Target ID: P27487 Gene ID: 1803.0 Gene Symbol: DPP4 Target Organism: Homo sapiens (Human) Sources: https://newdrugapprovals.org/2015/12/11/melogliptin/	Inhibitor 8297		1.61 nM [IC50]

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:23:24 GMT 2023` Edited by `admin` on `Sat Dec 16 16:23:24 GMT 2023`
Record UNII	I3N8016NKU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MELOGLIPTIN

Official Name

English

Melogliptin [WHO-DD]

Common Name

English

melogliptin [INN]

Common Name

English

(2S,4S)-4-FLUORO-1-(2-(((1R,3S)-3-((1H-1,2,4-TRIAZOL-1-YL)METHYL)CYCLOPENTYL)AMINO)ACETYL)PYRROLIDINE-2-CARBONITRILE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98086