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Details

Stereochemistry RACEMIC
Molecular Formula C12H20N2O4S
Molecular Weight 288.363
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SOTERENOL

SMILES

CC(C)NCC(O)C1=CC=C(O)C(NS(C)(=O)=O)=C1

InChI

InChIKey=HHRNQOGXBRYCHF-UHFFFAOYSA-N
InChI=1S/C12H20N2O4S/c1-8(2)13-7-12(16)9-4-5-11(15)10(6-9)14-19(3,17)18/h4-6,8,12-16H,7H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C12H20N2O4S
Molecular Weight 288.363
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Soterenol [(+)-1-(3-methanesulphonamido, 4-hydroxyphenyl)-2-isopropylaminoethanol, MJ 1992] is a directly acting sympathomimetic amine which has been shown to display Beta2-adrenoceptor selectivity. Soterenol, a methanesulfonamido-phenethanolamine related structurally to isoproterenol, was a highly effective bronchodilator agent in several animal species by various routes of administration. The bronchodilator potency of soterenol was equivalent to, or greater than, that of isoproterenol. Soterenol also had potent stimulant action on the alpha-receptor of the smooth muscle.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
Treatment with soterenol (0.3-300 ug/kg, i.v.) increased the mean arterial blood pressure and decreased heart rate in rabbits.
Route of Administration: Intravenous
In Vitro Use Guide
Soterenol (0.02-0.5 ug/ml) inhibited responses of the isolated guinea-pig trachea to transmural electrical stimulation. Increases in the force of contraction of guinea-pig left atria which were isolated and electrically driven were obtained with soterenol (5-100 ug/ml)
Substance Class Chemical
Record UNII
9364W7589B
Record Status Validated (UNII)
Record Version