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Details

Stereochemistry RACEMIC
Molecular Formula C16H24N2O2.ClH
Molecular Weight 312.835
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DROXICAINIDE HYDROCHLORIDE

SMILES

Cl.CC1=CC=CC(C)=C1NC(=O)C2CCCCN2CCO

InChI

InChIKey=ZBNGGCXOSMHCEV-UHFFFAOYSA-N
InChI=1S/C16H24N2O2.ClH/c1-12-6-5-7-13(2)15(12)17-16(20)14-8-3-4-9-18(14)10-11-19;/h5-7,14,19H,3-4,8-11H2,1-2H3,(H,17,20);1H

HIDE SMILES / InChI

Molecular Formula C16H24N2O2
Molecular Weight 276.374
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Droxicainide is a new antiarrhythmic agent. When given intravenously droxicainide suppressed ouabain-induced arrhythmias in pentobarbital-anesthetized guinea pigs. The initial experimental studies reported that droxicainide appears to have a more potent antiarrhythmic activity and fewer side effects than lidocaine. In local anesthetic tests and following intradermal administration to rabbits, droxicainide produced less local tissue irritation than lidocaine. Droxicainide is a class 1 anti-arrhythmic drug.

Approval Year

PubMed

PubMed

TitleDatePubMed
The acute antiarrhythmic effects of droxicainide and lidocaine in unanesthetized dogs.
1984 Mar-Apr
Comparison of electrophysiological and mechanical effects of droxicainide and lidocaine on heart muscle isolated from rats.
1984 Oct

Sample Use Guides

2.5 mg/kg as a bolus and then as a continuous infusion for 6 hours (1.4 mg/kg).
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:46:31 GMT 2023
Edited
by admin
on Sat Dec 16 09:46:31 GMT 2023
Record UNII
91801A0812
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DROXICAINIDE HYDROCHLORIDE
Common Name English
AL-S-1249
Code English
2-PIPERIDINECARBOXAMIDE, N-(2,6-DIMETHYLPHENYL)-1-(2-HYDROXYETHYL)-, MONOHYDROCHLORIDE
Systematic Name English
S-1249
Code English
DROXICAINIDE HYDROCHLORIDE, (±)-
Common Name English
2-PIPERIDINECARBOXAMIDE, N-(2,6-DIMETHYLPHENYL)-1-(2-HYDROXYETHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
CAS
149572-05-4
Created by admin on Sat Dec 16 09:46:31 GMT 2023 , Edited by admin on Sat Dec 16 09:46:31 GMT 2023
PRIMARY
PUBCHEM
3060807
Created by admin on Sat Dec 16 09:46:31 GMT 2023 , Edited by admin on Sat Dec 16 09:46:31 GMT 2023
PRIMARY
FDA UNII
91801A0812
Created by admin on Sat Dec 16 09:46:31 GMT 2023 , Edited by admin on Sat Dec 16 09:46:31 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY