ZATOSETRON

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H25ClN2O2
Molecular Weight	348.867
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ZATOSETRON

Structure Search

SMILES

CN1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)C3=CC(Cl)=CC4=C3OC(C)(C)C4

InChI

InChIKey=SPKBYQZELVEOLL-QDMKHBRRSA-N

InChI=1S/C19H25ClN2O2/c1-19(2)10-11-6-12(20)7-16(17(11)24-19)18(23)21-13-8-14-4-5-15(9-13)22(14)3/h6-7,13-15H,4-5,8-10H2,1-3H3,(H,21,23)/t13-,14+,15-

HIDE SMILES / InChI

Molecular Formula	C19H25ClN2O2
Molecular Weight	348.867
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	2 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1732548 | https://www.ncbi.nlm.nih.gov/pubmed/7984290 | https://www.ncbi.nlm.nih.gov/pubmed/7517409 | https://www.ncbi.nlm.nih.gov/pubmed/10211913

Zatosetron is a potent, selective, orally effective 5HT3 receptor antagonist. It has been studied in the treatment of emesis, migraine and anxiety.

CNS Activity

Originator

Approval Year

Patents

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:39:35 GMT 2023` Edited by `admin` on `Fri Dec 15 17:39:35 GMT 2023`
Record UNII	901MC95XSB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZATOSETRON

Official Name

English

LY277359

Code

English

zatosetron [INN]

Common Name

English

Zatosetron [WHO-DD]

Common Name

English

5-CHLORO-2,3-DIHYDRO-2,2-DIMETHYL-N-1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-YL-7-BENZOFURANCARBOXAMIDE

Common Name

English

LY-277359

Code

English

7-BENZOFURANCARBOXAMIDE, 5-CHLORO-2,3-DIHYDRO-2,2-DIMETHYL-N-(8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL)-, ENDO-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C94726

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

Code System Code Type Description

FDA UNII

901MC95XSB

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

SMS_ID

100000079392

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

ChEMBL

CHEMBL2111147

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

INN

6681

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

NCI_THESAURUS

C95278

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

EPA CompTox

DTXSID8043997

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

CAS

123482-22-4

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

WIKIPEDIA

Zatosetron

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

EVMPD

SUB00144MIG

Created by admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023

PRIMARY

Related Record Type Details


					901MC95XSB

EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:


					EA9HO2Z7V5

5-HYDROXYTRYPTAMINE RECEPTOR 3A

TARGET -> INHIBITOR

Amount:


					901MC95XSB

EXCRETED UNCHANGED

Qualification:

FECAL

Amount:

Related Record Type Details


					J3DMW4P6CS

N-DESMETHYL-ZATOSETRON

METABOLITE -> PARENT

Qualification:

PLASMA

Amount:


					38GX77S9WZ

ZATOSETRON N-OXIDE

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					SX8PUA2ENT

3-HYDROXYZATOSETRON

METABOLITE -> PARENT

Qualification:

PLASMA

Amount:

Related Record Type Details


					901MC95XSB

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC