KETORFANOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H25NO2
Molecular Weight	311.418
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12CC3=C(C(O)=CC=C3)[C@@]5(CCN1CC4CC4)CC(=O)CC[C@@]25[H]

InChI

InChIKey=ORMBBVGVPWUEMQ-QKLQHJQFSA-N

InChI=1S/C20H25NO2/c22-15-6-7-16-17-10-14-2-1-3-18(23)19(14)20(16,11-15)8-9-21(17)12-13-4-5-13/h1-3,13,16-17,23H,4-12H2/t16-,17+,20-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H25NO2
Molecular Weight	311.418
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.genome.jp/dbget-bin/www_bget?dr:D04653 | https://www.ncbi.nlm.nih.gov/pubmed/7310820

KETORFANOL, a morphinan derivative, is an opioid analgesic. It showed potent antiwrithing activity in the animal assay. It was equipotent with morphine as an agonist and lacked antagonist activity up to 10 mg/kg.

Originator

Approval Year

PubMed

Title	Date	PubMed
(-)-4-Hydroxymorphinanones: their synthesis and analgesic activity.	1981 Dec	7310820

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:14:22 GMT 2023` Edited by `admin` on `Sat Dec 16 17:14:22 GMT 2023`
Record UNII	8Z0ZXE70XL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KETORFANOL

Official Name

English

SBW-22

Code

English

ketorfanol [INN]

Common Name

English

KETORFANOL [USAN]

Common Name

English

MORPHINAN-6-ONE, 17-(CYCLOPROPYLMETHYL)-4-HYDROXY-

Systematic Name

English

17-(Cyclopropylmethyl)-4-hydroxymorphinan-6-one

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1506