PROTOKYLOL

Details

Stereochemistry	UNKNOWN
Molecular Formula	C18H21NO5
Molecular Weight	331.363
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC(CC1=CC2=C(OCO2)C=C1)NCC(O)C3=CC(O)=C(O)C=C3

InChI

InChIKey=LUMAEVHDZXIGEP-UHFFFAOYSA-N

InChI=1S/C18H21NO5/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H21NO5
Molecular Weight	331.363
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Protokylol, a sympathomimetic drug has been utilized in general clinical practice as a bronchodilator. Protokylol (brand names Caytine, Ventaire) is a β-adrenergic receptor agonist which was used as a bronchodilator in Europe and the United States.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-2 adrenergic receptor 203	Agonist 2,678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Respiratory-system disorders 2	Primary		Approved 8,429	VENTAIRE

Doses

Doses

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Dose	Population	Adverse events
4 g 4 times / day multiple, oral (max) Recommended	unhealthy
0.5 mg single, intramuscular\|subcutaneous (max) Recommended	unhealthy

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Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
BSEP 402

Drug as perpetrator

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Target	Modality	Activity	Metabolite	Clinical evidence
BSEP 403	inhibitor 3,277	weak [IC50 >982.3 uM]

Showing 1 to 1 of 1 entries

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
001 Chemical	DY519699	https://www.001chemical.com/chem/136-70-9
AAA Chemistry	AR-1H9707
ABI Chem	AC1L1JBR
ABI Chem	AC1Q6ZXQ
Alfa Chemistry	136-70-9	https://www.alfa-chemistry.com/cas_136-70-9.htm

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PubMed

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Title	Date	PubMed
The resolution of dopamine and beta 1- and beta 2-adrenergic-sensitive adenylate cyclase activities in homogenates of cat cerebellum, hippocampus and cerebral cortex.	1979 Dec 28	41616
N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver.	1979 Jan	216448
Effects of N-aralkyl substitution of beta-agonists on alpha- and beta-adrenoceptor subtypes: pharmacological studies and binding assays.	1982 Feb	6121868

Showing 1 to 3 of 3 entries

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Patents

Sample Use Guides

In Vivo Use Guide

0.2-0.6 ml, aerosol

Route of Administration: Respiratory

In Vitro Use Guide

Protokylol dose-dependently (10(-6) - 10(-4) mM) induced guinea-pig trachea relaxation.

Substance Class	Chemical
Record UNII	8Y5Y4EEO2V
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

PROTOKYLOL

Official Name

English

VENTAIRE

Brand Name

English

Protokylol [WHO-DD]

Common Name

English

PROTOKYLOL [MI]

Common Name

English

protokylol [INN]

Common Name

English

Showing 1 to 5 of 5 entries

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Classification Tree

Code System

Code

Adrenergic Agonist

NCI_THESAURUS

C48149

Anti-asthmatic Agent

NCI_THESAURUS

C319

Showing 1 to 2 of 2 entries

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Code System

Code

Type

Description

MERCK INDEX

m9274

PRIMARY

Merck Index

NCI_THESAURUS

C74198

PRIMARY

SMS_ID

100000080837

PRIMARY

ChEMBL

CHEMBL1201273

PRIMARY

WIKIPEDIA

Protokylol

PRIMARY

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Related Record

Type

Details


					8Y5Y4EEO2V

PROTOKYLOL

ACTIVE MOIETY

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SMILES

InChI

CNS Activity

Originator

Approval Year

Targets

Conditions

Doses

Overview

OverviewOther

Drug as perpetrator​

Sourcing

PubMed

Patents

Sample Use Guides

Drug as perpetrator