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Details

Stereochemistry ACHIRAL
Molecular Formula C14H13N3O5S
Molecular Weight 335.335
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOXICAM

SMILES

CN1C(C(=O)NC2=NOC(C)=C2)=C(O)C3=C(C=CC=C3)S1(=O)=O

InChI

InChIKey=YYUAYBYLJSNDCX-UHFFFAOYSA-N
InChI=1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)

HIDE SMILES / InChI
Molecular Formula C14H13N3O5S
Molecular Weight 335.335
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Isoxicam is a nonsteroidal anti-inflammatory drug with long half-life. The major oxidative excretion product of isoxicam is the hydroxymethlyisoxazole metabolite, minor metabolites are open-ring sulfonamide and N-methylsaccharin. Isoxicam Is effective and well tolerated in all the major rheumatic diseases.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 2.0 µM [IC50]
PubMed

PubMed

TitleDatePubMed
The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).
1975 Aug
Comparative biochemical pharmacology of the oxicams.
1987
Patents

Patents

03960856
5
JP2001503372A
27
JP2001525058A
70
JP2002528495A
37
JP2002541233A
400
JP2003515526A
462
JP2003528044A
30
JP2007503428A
35
JP2011524416A
138
JP2011526251A
112
JP3805381B2
41
JP4787165B2
101
JPH10218774A
1
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:49:46 UTC 2023
Edited
by admin
on Fri Dec 15 15:49:46 UTC 2023
Record UNII
8XU734C4NG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ISOXICAM
INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
W-8495
Code English
4-Hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Systematic Name English
ISOXICAM [MART.]
Common Name English
NSC-758436
Code English
ISOXICAM [MI]
Common Name English
ISOXICAM [USAN]
Common Name English
W 8495
Code English
2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE, 4-HYDROXY-2-METHYL-N-(5-METHYL-3-ISOXAZOLYL)-, 1,1-DIOXIDE
Systematic Name English
MAXICAM
Brand Name English
isoxicam [INN]
Common Name English
Isoxicam [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL53292
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
SMS_ID
100000082858
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
NCI_THESAURUS
C80558
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
MERCK INDEX
m789
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY Merck Index
DRUG BANK
DB08942
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
NSC
758436
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
CAS
34552-84-6
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
ECHA (EC/EINECS)
252-084-5
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
EPA CompTox
DTXSID0045462
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
EVMPD
SUB08344MIG
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
PUBCHEM
54677972
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
WIKIPEDIA
Isoxicam
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
MESH
C013580
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
INN
3435
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
DRUG CENTRAL
1509
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
CHEBI
76163
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
FDA UNII
8XU734C4NG
Created by admin on Fri Dec 15 15:49:46 UTC 2023 , Edited by admin on Fri Dec 15 15:49:46 UTC 2023
PRIMARY
Related Record Type Details
Structure of ISOXICAM
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