U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C27H31NO3.ClH
Molecular Weight 454.001
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ASOCAINOL HYDROCHLORIDE

SMILES

Cl.COC1=CC2=C(CCN(C)C(CCC3=CC=CC=C3)CC4=CC=C(OC)C(O)=C24)C=C1

InChI

InChIKey=JTGDTQLVMHZOHX-UHFFFAOYSA-N
InChI=1S/C27H31NO3.ClH/c1-28-16-15-20-10-13-23(30-2)18-24(20)26-21(11-14-25(31-3)27(26)29)17-22(28)12-9-19-7-5-4-6-8-19;/h4-8,10-11,13-14,18,22,29H,9,12,15-17H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula C27H31NO3
Molecular Weight 417.5399
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Asocainol is a rather efficient antiarrhythmic agent that has the effects of both class Ia and class IV antiarrhythmic drugs. Asocainol interfere with the sodium channel and lengthens the action potential. Besides that, Asocainol decreases conduction through the AV node, and shorten phase two (the plateau) of the cardiac action potential. Asocainol reduce the contractility of the heart, so may be inappropriate in heart failure. Asocainol is an effective antiarrhythmic agent in a variety of animal arrhythmia models and species.

Approval Year

PubMed

PubMed

TitleDatePubMed
Asocainol, a new antiarrhythmic drug with natrium- and calcium-antagonistic effects on ventricular myocardium.
1984 Nov-Dec
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 09:33:12 GMT 2023
Edited
by admin
on Sat Dec 16 09:33:12 GMT 2023
Record UNII
8VX5A020BS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASOCAINOL HYDROCHLORIDE
Common Name English
5H-DIBENZ(D,F)AZONIN-1-OL, 6,7,8,9-TETRAHYDRO-2,12-DIMETHOXY-7-METHYL-6-(2-PHENYLETHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
ECHA (EC/EINECS)
293-842-5
Created by admin on Sat Dec 16 09:33:12 GMT 2023 , Edited by admin on Sat Dec 16 09:33:12 GMT 2023
PRIMARY
FDA UNII
8VX5A020BS
Created by admin on Sat Dec 16 09:33:12 GMT 2023 , Edited by admin on Sat Dec 16 09:33:12 GMT 2023
PRIMARY
PUBCHEM
170357
Created by admin on Sat Dec 16 09:33:12 GMT 2023 , Edited by admin on Sat Dec 16 09:33:12 GMT 2023
PRIMARY
CAS
91574-89-9
Created by admin on Sat Dec 16 09:33:12 GMT 2023 , Edited by admin on Sat Dec 16 09:33:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID40919647
Created by admin on Sat Dec 16 09:33:12 GMT 2023 , Edited by admin on Sat Dec 16 09:33:12 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY