U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H24N2O2.H3O4P
Molecular Weight 362.3584
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMETHOLIZINE PHOSPHATE

SMILES

OP(O)(O)=O.COCCCN1CCN(CC1)C2=CC=CC=C2OC

InChI

InChIKey=NCOMQNWYMLGJPF-UHFFFAOYSA-N
InChI=1S/C15H24N2O2.H3O4P/c1-18-13-5-8-16-9-11-17(12-10-16)14-6-3-4-7-15(14)19-2;1-5(2,3)4/h3-4,6-7H,5,8-13H2,1-2H3;(H3,1,2,3,4)

HIDE SMILES / InChI
Molecular Formula C15H24N2O2
Molecular Weight 264.3633
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H3O4P
Molecular Weight 97.9952
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dimetholizine has antihypertensive activity. It is an antihistaminic agent too. Histamine H1 receptor was predicted as a primary target for dimetholizine. Moreover, it was found to bind the Dopamine D2 and 5-HT1A receptors. Dimetholizine was predicted to be alpha1D-Adrenergic blocker.

Approval Year

Unknown
149124
Patents

Patents

20100226943
186
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:54:39 GMT 2025
Edited
by admin
on Mon Mar 31 20:54:39 GMT 2025
Record UNII
8VNU0OD47W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ANSIV
Preferred Name English
DIMETHOLIZINE PHOSPHATE
Common Name English
PIPERAZINE, 1-(2-METHOXYPHENYL)-4-(3-METHOXYPROPYL)-, PHOSPHATE
Systematic Name English
PIPERAZINE, 1-(O-METHOXYPHENYL)-4-(3-METHOXYPROPYL)-, PHOSPHATE
Common Name English
Code System Code Type Description
PUBCHEM
71586971
Created by admin on Mon Mar 31 20:54:39 GMT 2025 , Edited by admin on Mon Mar 31 20:54:39 GMT 2025
PRIMARY
CAS
13980-98-8
Created by admin on Mon Mar 31 20:54:39 GMT 2025 , Edited by admin on Mon Mar 31 20:54:39 GMT 2025
PRIMARY
EPA CompTox
DTXSID70161172
Created by admin on Mon Mar 31 20:54:39 GMT 2025 , Edited by admin on Mon Mar 31 20:54:39 GMT 2025
PRIMARY
FDA UNII
8VNU0OD47W
Created by admin on Mon Mar 31 20:54:39 GMT 2025 , Edited by admin on Mon Mar 31 20:54:39 GMT 2025
PRIMARY
Related Record Type Details
Structure of DIMETHOLIZINE
PARENT -> SALT/SOLVATE
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966