TEGLICAR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H45N3O3
Molecular Weight	399.611
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCNC(=O)N[C@H](CC([O-])=O)C[N+](C)(C)C

InChI

InChIKey=BMZYTDRMCBZVNH-HXUWFJFHSA-N

InChI=1S/C22H45N3O3/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-23-22(28)24-20(18-21(26)27)19-25(2,3)4/h20H,5-19H2,1-4H3,(H2-,23,24,26,27,28)/t20-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H45N3O3
Molecular Weight	399.611
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	1 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21270274 | https://adisinsight.springer.com/drugs/800017026

Teglicar, an antihyperglycemic agent, is a carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor that was studied for the treatment of type 2 diabetes. The drug participated in phase II clinical trial in Italy; however, the further development apparently was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies.	2019-01	30453033
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.	2016	27695056
Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis.	2011-02	21270274

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:21:54 GMT 2025` Edited by `admin` on `Mon Mar 31 18:21:54 GMT 2025`
Record UNII	8V3VQ6HMII
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TEGLICAR

Official Name

English

teglicar [INN]

Preferred Name

English

(3R)-3-((TETRADECYLAMINOCARBONYL)AMINO)-4-(TRIMETHYLAZANIUMYL)BUTANOATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C471