DAVASAICIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H30N2O3
Molecular Weight	370.4852
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(CC(=O)NCCCC2=CC=C(C)C(C)=C2)=CC=C1OCCN

InChI

InChIKey=VVMIHZHLNJMAQP-UHFFFAOYSA-N

InChI=1S/C22H30N2O3/c1-16-6-7-18(13-17(16)2)5-4-11-24-22(25)15-19-8-9-20(27-12-10-23)21(14-19)26-3/h6-9,13-14H,4-5,10-12,15,23H2,1-3H3,(H,24,25)

HIDE SMILES / InChI

Molecular Formula	C22H30N2O3
Molecular Weight	370.4852
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://link.springer.com/article/10.1007/BF02974166 | https://www.ncbi.nlm.nih.gov/pubmed/18975221 | https://www.ncbi.nlm.nih.gov/pubmed/10615858 |

Davasaicin is a synthetic derivative of capsaicin, developed at the Korea Research Institute of Chemical Technology. Davasaicin possesses very potent analgesic activity, demonstrated in several animal models, such as phenylbenzoquinone-induced writhing test, tail-flick test in mice and adjuvant arthritic flexion test in rats. When administered topically, davasaicin has an antipruritic effect in the mouse model.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Vanilloid receptor 53 Target ID: CHEMBL5102 Sources: https://adisinsight.springer.com/drugs/800006877\|https://www.ncbi.nlm.nih.gov/pubmed/22796184	Agonist 2678		589.0 nM [EC50]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:02:04 GMT 2023` Edited by `admin` on `Sat Dec 16 18:02:04 GMT 2023`
Record UNII	8V3419G4NR
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DAVASAICIN

Official Name

English

DA-5018 FREE BASE

Code

English

2-(4-(2-AMINOETHOXY)-3-METHOXYPHENYL)-N-(3-(3,4-DIMETHYLPHENYL)PROPYL)ACETAMIDE

Systematic Name

English

davasaicin [INN]

Common Name

English

KR-25018

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C241