Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H14O9S |
| Molecular Weight | 370.331 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@@H]1CC2=C(O[C@@H]1C3=CC(O)=C(O)C=C3)C=C(O)C=C2OS(O)(=O)=O
InChI
InChIKey=MWSSRHFQMROXGK-IUODEOHRSA-N
InChI=1S/C15H14O9S/c16-8-4-13-9(14(5-8)24-25(20,21)22)6-12(19)15(23-13)7-1-2-10(17)11(18)3-7/h1-5,12,15-19H,6H2,(H,20,21,22)/t12-,15-/m1/s1
| Molecular Formula | C15H14O9S |
| Molecular Weight | 370.331 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibitory effect of tannic acid sulfate and related sulfates on infectivity, cytopathic effect, and giant cell formation of human immunodeficiency virus. | 1992 Dec |
|
| Identification of O-methyl-(-)-epicatechin-O-sulphate metabolites by mass-spectrometry after O-methylation with trimethylsilyldiazomethane. | 2012 Jul 6 |
|
| Cocoa flavanol metabolites activate HNF-3β, Sp1, and NFY-mediated transcription of apolipoprotein AI in human cells. | 2013 Jun |
Patents
Sample Use Guides
Epicatechin-5-Sulfate is patented for inclusion in food compositions intended to be used for weight loss, and treatment of diabetes. The patent suggests a concentration of at least 0.01 mg/g of the food product.
Route of Administration:
Oral
Human hepatocellular carcinoma HepG2 and human cervix adenocarcinoma HeLa cells were grown in Ham's F-12 medium supplemented with 7% fetal bovine serum at 37 deg-C in a 5% CO2 atmosphere. Cells were incubated with 10 micro-M of epicatechin sulfate for 48 hours. Cells cultures were assayed for RNA content and content of nuclear extracts. Epicatechin sulfate was found to induce ApoAI transcription through Site B.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:23:47 GMT 2023
by
admin
on
Sat Dec 16 08:23:47 GMT 2023
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| Record UNII |
8T66C0D002
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| Record Status |
Validated (UNII)
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| Record Version |
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300000013085
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8T66C0D002
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71579119
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1194377-44-0
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admin on Sat Dec 16 08:23:47 GMT 2023 , Edited by admin on Sat Dec 16 08:23:47 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> METABOLITE LESS ACTIVE |
FRAP (ferric reducing ability of plasma) assay; Unit: TEAC (Trolox equivalent antioxidant capacity)- mM-Trolox equivalent/mM; epicatechin was 1.34
IN-VITRO
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