Pivicasiran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 15:40:20 GMT 2025` Edited by `admin` on `Wed Apr 02 15:40:20 GMT 2025`
Nucleic Acid Type	siRNA
Sequence Type	COMPLETE
Record UNII	8T3L374QA3
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Pivicasiran

Official Name

English

RNA, (Am-sp-(2?-deoxy-2?-fluoro)C-sp-Am-Um-Am-(2?-deoxy-2?-fluoro)A-Gm-(2?-deoxy-2?-fluoro)A-(2?-deoxy-2?-fluoro)C-Am-Um-Um-Am-(2?-deoxy-2?-fluoro)U-Cm-(2?-deoxy-2?-fluoro)C-Um-Am-Am-Um-Gm-sp-Gm-sp-Gm), complex with RNA (Cm-sp-Am-sp-Um-Um-Am-Gm-(2?-deoxy

Preferred Name

English

pivicasiran [INN]

Common Name

English

[(2S,4R)-1-(1-[(2-acetamido-2-deoxy-?-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2-acetamido-2-deoxy-?-Dgalactopyranosyl) oxy]pentanamido}propyl)amino]-3-oxopropyl}methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl)-4-hydroxypyrrolidin-2-yl]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C211748

Created by admin on Wed Apr 02 15:40:20 GMT 2025 , Edited by admin on Wed Apr 02 15:40:20 GMT 2025

PRIMARY

FDA UNII

8T3L374QA3

Created by admin on Wed Apr 02 15:40:20 GMT 2025 , Edited by admin on Wed Apr 02 15:40:20 GMT 2025

PRIMARY

INN

13141

Created by admin on Wed Apr 02 15:40:20 GMT 2025 , Edited by admin on Wed Apr 02 15:40:20 GMT 2025

PRIMARY

CAS

2654847-29-5

Created by admin on Wed Apr 02 15:40:20 GMT 2025 , Edited by admin on Wed Apr 02 15:40:20 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1;1_3-1_5;1_7;1_10-1_13;1_15;1_17-1_23;2_1-2_6;2_8;2_12-2_21	34 / 44
2'-Fluoro-Ribose	1_2;1_6;1_8-1_9;1_14;1_16;2_7;2_9-2_11	10 / 44

Linkage	Site Range	Site Count
Phosphate	1_4-1_21;2_4-2_21	36 / 42
Phosporothioate	1_2-1_3;1_22-1_23;2_2-2_3	6 / 42

Related Record Type Details


					8T3L374QA3

Pivicasiran

ACTIVE MOIETY

Comments:

adiponutrin synthesis reducer

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_21]	3'-TERMINUS		Amount:	UNSPECIFIED SUBSTANCE	c6b500e6 (not in database)