U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Fri Jun 25 21:28:50 UTC 2021
Edited
by admin
on Fri Jun 25 21:28:50 UTC 2021
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE
Source Materials Parent
Part BLOOD
Fraction Material Type CELL
Fraction Name T-CELLS
Record UNII
8PX1X7UG4D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IDECABTAGENE VICLEUCEL
USAN   INN  
Official Name English
HUMAN CULTURE EXPANDED GENETICALLY MODIFIED AUTOLOGOUS T CELLS FOR CELL-BASED GENE THERAPY. CELLS ARE DERIVED FROM ISOLATED BLOOD OF THE PATIENT AND ARE TRANSDUCED WITH NON-REPLICATIVE SELF-INACTIVATING (SIN) HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) B
Common Name English
IDECABTAGENE VICLEUCEL [INN]
Common Name English
IDE-CEL
Common Name English
IDECABTAGENE VICLEUCEL [USAN]
Common Name English
BB2121
Code English
ANTI-BCMA CAR T CELL
Common Name English
BB-2121
Code English
Code System Code Type Description
NCI_THESAURUS
C117729
Created by admin on Fri Jun 25 21:28:50 UTC 2021 , Edited by admin on Fri Jun 25 21:28:50 UTC 2021
PRIMARY
INN
10906
Created by admin on Fri Jun 25 21:28:50 UTC 2021 , Edited by admin on Fri Jun 25 21:28:50 UTC 2021
PRIMARY
FDA UNII
8PX1X7UG4D
Created by admin on Fri Jun 25 21:28:50 UTC 2021 , Edited by admin on Fri Jun 25 21:28:50 UTC 2021
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CULTURED TRANSFECTION RETROVIRAL TRANSFECTION ANTI-BCMA02 CAR LENTIVIRAL VECTOR 24U06E3FHJ

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN IDECABTAGENE VICLEUCEL CAR T RECEPTOR H4ON8SV8LK
INSERTED GENE EXPRESSION VECTOR ANTI-BCMA02 CAR LENTIVIRAL VECTOR CDNA D2AT57OS3D