TISOCALCITATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C31H48O5
Molecular Weight	500.7098
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	3
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)\C=C\[C@@H](O)C(C)(C)C(=O)OC(C)C

InChI

InChIKey=AUMBXYDXKLLKEK-BGMQPCSBSA-N

InChI=1S/C31H48O5/c1-19(2)36-29(35)30(5,6)28(34)15-10-20(3)25-13-14-26-22(9-8-16-31(25,26)7)11-12-23-17-24(32)18-27(33)21(23)4/h10-12,15,19-20,24-28,32-34H,4,8-9,13-14,16-18H2,1-3,5-7H3/b15-10+,22-11+,23-12-/t20-,24-,25-,26+,27+,28-,31-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C31H48O5
Molecular Weight	500.7098
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	3
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15968262 | https://adisinsight.springer.com/drugs/800018814 | DOI: 10.1016/j.jaad.2003.11.041 | DOI: 10.1016/j.jaad.2003.11.042 | DOI: 10.1016/j.jaad.2003.10.541

Tisocalcitate is the vitamin D derivative. Tisocalcitate ointment is currently in phase 2 clinical development for mild to moderate psoriasis. Early studies have shown that, unlike other vitamin D3 analogues, tisocalcitate does not affect calcium metabolism. Tisocalcitate ointments were tolerated well and were safe to use on healthy skin. Tisocalcitate had been in phase II clinical trial for the treatment of psoriasis. However, this development was discontinued.

Approval Year

PubMed

Title	Date	PubMed
Therapeutic options in the treatment of psoriasis and atopic dermatitis.	2005 Jul	15968262

Sample Use Guides

In Vivo Use Guide

25 ug/g of Tisocalcitate ointment on 45% BSA, 50 ug/g of Tisocalcitate ointment on 45% BSA and twice daily 50 ug/g of Tisocalcitate ointment on 45% BSA.

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:15:23 GMT 2023` Edited by `admin` on `Sat Dec 16 16:15:23 GMT 2023`
Record UNII	8O4QYK6G4Y
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TISOCALCITATE

Official Name

English

TISOCALCITATE [USAN]

Common Name

English

tisocalcitate [INN]

Common Name

English

ZK-156942

Code

English

ZK156942

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C39713