SAVIPRAZOLE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H10F7N3O2S2
Molecular Weight	461.378
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][S+](CC1=NC=CC(OCC(F)(F)C(F)(F)C(F)(F)F)=C1)C2=NC3=CSC=C3N2

InChI

InChIKey=ARFGGIRJBPTBPP-UHFFFAOYSA-N

InChI=1S/C15H10F7N3O2S2/c16-13(17,14(18,19)15(20,21)22)7-27-9-1-2-23-8(3-9)6-29(26)12-24-10-4-28-5-11(10)25-12/h1-5H,6-7H2,(H,24,25)

HIDE SMILES / InChI

Molecular Formula	C15H10F7N3O2S2
Molecular Weight	461.378
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1664524 | https://adisinsight.springer.com/drugs/800000579

Saviprazole (also known as HOE 731) is a potent inhibitor of gastric H+/K(+)-ATPase that has been studied in phase I clinical trial for the treatment of gastric ulcer. However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Gastric acid inhibitory profile of saviprazole (HOE 731) compared to omeprazole.	1991	1664524
2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors.	1992 Feb 7	1310742

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:53 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:53 GMT 2023`
Record UNII	8NO3IX3KJ7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SAVIPRAZOLE

Official Name

English

2-(((4-(2,2,3,3,4,4,4-HEPTAFLUOROBUTOXY)-2-PYRIDYL)METHYL)SULFINYL)-1H-THIENO(3,4-D)IMIDAZOLE

Systematic Name

English

saviprazole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29723