SAVIPRAZOLE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H10F7N3O2S2
Molecular Weight	461.378
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][S+](CC1=CC(OCC(F)(F)C(F)(F)C(F)(F)F)=CC=N1)C2=NC3=CSC=C3N2

InChI

InChIKey=ARFGGIRJBPTBPP-UHFFFAOYSA-N

InChI=1S/C15H10F7N3O2S2/c16-13(17,14(18,19)15(20,21)22)7-27-9-1-2-23-8(3-9)6-29(26)12-24-10-4-28-5-11(10)25-12/h1-5H,6-7H2,(H,24,25)

HIDE SMILES / InChI

Molecular Formula	C15H10F7N3O2S2
Molecular Weight	461.378
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1664524 | https://adisinsight.springer.com/drugs/800000579

Saviprazole (also known as HOE 731) is a potent inhibitor of gastric H+/K(+)-ATPase that has been studied in phase I clinical trial for the treatment of gastric ulcer. However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors.	1992-02-07	1310742
Gastric acid inhibitory profile of saviprazole (HOE 731) compared to omeprazole.	1991	1664524

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:48 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:48 GMT 2025`
Record UNII	8NO3IX3KJ7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SAVIPRAZOLE

Official Name

English

saviprazole [INN]

Preferred Name

English

2-(((4-(2,2,3,3,4,4,4-HEPTAFLUOROBUTOXY)-2-PYRIDYL)METHYL)SULFINYL)-1H-THIENO(3,4-D)IMIDAZOLE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29723