| Stereochemistry | ABSOLUTE |
| Molecular Formula | C38H44O8 |
| Molecular Weight | 628.7512 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)=CCC[C@@]1(C)OC2=C(C=C1)C(O)=C3C(=O)C4=C[C@@H]5C[C@H]6C(C)(C)O[C@@](C\C=C(\C)C(O)=O)(C5=O)[C@@]46OC3=C2CC=C(C)C
InChI
InChIKey=GEZHEQNLKAOMCA-RRZNCOCZSA-N
InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1
| Molecular Formula | C38H44O8 |
| Molecular Weight | 628.7512 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Gambogic acid (GA), a naturally occurring xanthone-based moiety, reported from Garcinia hanburyi tree, is known to perform numerous intracellular and extracellular actions, including programmed cell death, autophagy, cell cycle arrest, antiangiogenesis, antimetastatic, and anti-inflammatory activities. In addition, GA-based synergistic approaches have been proven to enhance the healing strength of existing chemotherapeutic agents along with lesser side effects. Among cellular targets of gambogic acid topoisomerase, multidrug-resistant protein ATP-binding cassette transporter B1 (ABCB1) and Transferrin receptor.
CNS Activity
Approval Year
PubMed
Patents
Sample Use Guides
The animals in the treatment group received one of three dosages of gambogic acid (in saline; 5, 10 or 20 mg/kg) via the caudal vein twice weekly.
For intraperitoneal administration the mice were randomly assigned to treatment with 10, 20 or 30 mg/kg gambogic acid for 3 weeks.
Route of Administration:
Other
