ACODAZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H19N5O
Molecular Weight	345.3978
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C(C)=O)C1=CC=C(NC2=CC(C)=NC3=C2C4=C(C=C3)N=CN4)C=C1

InChI

InChIKey=XJXLRNPVSQADMZ-UHFFFAOYSA-N

InChI=1S/C20H19N5O/c1-12-10-18(19-16(23-12)8-9-17-20(19)22-11-21-17)24-14-4-6-15(7-5-14)25(3)13(2)26/h4-11H,1-3H3,(H,21,22)(H,23,24)

HIDE SMILES / InChI

Molecular Formula	C20H19N5O
Molecular Weight	345.3978
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/acodazole | https://www.ncbi.nlm.nih.gov/pubmed/3594447 | https://www.ncbi.nlm.nih.gov/pubmed/3390838

Acodazole is a synthetic imidazoquinoline with antimicrobial and antineoplastic activity. Acodazole intercalates into DNA, resulting in disruption of DNA replication. Use of this agent has been associated with significant cardiotoxicity, especially prolonged cardiac output interval (Q-Ti) on electrocardiogram and polymorphic ventricular tachycardia ("torsades des pointes").

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:17:40 GMT 2023` Edited by `admin` on `Fri Dec 15 16:17:40 GMT 2023`
Record UNII	8M28A9O41G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACODAZOLE

Official Name

English

acodazole [INN]

Common Name

English

ACETAMIDE, N-METHYL-N-(4-((7-METHYL-1H-IMIDAZO(4,5-F)QUINOLIN-9-YL)AMINO)PHENYL)-

Systematic Name

English

N-METHYL-4'-((7-METHYL-1H-IMIDAZO(4,5-F)QUINOLIN-9-YL)AMINO)ACETANILIDE

Systematic Name

English

Acodazole [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C582