Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H19N3O |
Molecular Weight | 281.3523 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=NC=CC=C3
InChI
InChIKey=TZFUBYYADABEAV-UHFFFAOYSA-N
InChI=1S/C17H19N3O/c21-17(16-8-4-5-9-18-16)20-12-10-19(11-13-20)14-15-6-2-1-3-7-15/h1-9H,10-14H2
Molecular Formula | C17H19N3O |
Molecular Weight | 281.3523 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Piberaline (EGYT-475) is the antidepressant drug. Piberaline antagonized the reserpine-induced dopamine depletion in the olfactory tubercle of rats. Piberaline in contrast to tricyclic antidepressants does not impair the acquisition of avoidance conditioning but rather improves it while it does not facilitate the extinction of learned behavior but considerably delays it. EGYT-2760, an active metabolite of EGYT-475, has a central serotoninomimetic action which involves 5-HT uptake-inhibition and 5-HT1 receptor agonistic effect.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Effects of reserpine and antidepressants on dopamine and DOPAC (3,4-dihydroxyphenylacetic acid) concentrations in the striatum, olfactory tubercle and median eminence of rats. | 1980 Jun 27 |
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Effects of a new antidepressant drug on active avoidance behavior in rats. Comparative study with tricyclic antidepressants. | 1983 Nov |
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Gas chromatographic method for determination of a piperazine derivative (Trelibet) and its metabolites in human plasma and urine. | 1986 May 28 |
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The action of trelibet, a new antidepressive agent on [3H]noradrenaline release from rabbit pulmonary artery. | 1986 Nov 4 |
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The effect of EGYT-475 (Trelibet) and its metabolites on the potassium-stimulated 3H-noradrenaline release from cortical slices of rat brain. | 1987 Mar-Apr |
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Studies on serum binding of some drugs. | 1987 Mar-Apr |
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Computer analysis of the pharmacokinetic parameters of EGYT-475, a new antidepressant agent. | 1987 Mar-Apr |
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Species differences in the in vitro metabolism of EGYT-475, a new antidepressant agent. | 1987 Mar-Apr |
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The metabolism of EGYT-475, a new antidepressant agent, in rats. | 1987 Mar-Apr |
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Pharmacokinetic aspects of the mode of action of EGYT-475, a new antidepressant agent. | 1987 Mar-Apr |
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Studies on the biochemical mode of action of EGYT-475, a new antidepressant. | 1987 Mar-Apr |
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Comparison of serotonin agonistic and antagonistic activities of a new antidepressant agent Trelibet (EGYT-475) and its metabolite EGYT-2760 on isolated rat fundus. | 1991 |
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[Synthesis and antidepressive activity study of aryl and heteroaryl carboxamides of benzylpiperazine]. | 2000 Jul |
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Studies on the metabolism and toxicological detection of the new designer drug N-benzylpiperazine in urine using gas chromatography-mass spectrometry. | 2002 Jun 15 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 16:04:33 UTC 2023
by
admin
on
Sat Dec 16 16:04:33 UTC 2023
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Record UNII |
8M09P36809
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Record Status |
Validated (UNII)
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Record Version |
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-
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NCI_THESAURUS |
C265
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Code System | Code | Type | Description | ||
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C72828
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m8774
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SUB09804MIG
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65975
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39640-15-8
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4240
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8M09P36809
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100000082470
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DTXSID40192751
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CHEMBL2105223
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Piberaline
Created by
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3466
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Related Record | Type | Details | ||
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ACTIVE MOIETY |