PIBERALINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H19N3O
Molecular Weight	281.3523
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=NC=CC=C3

InChI

InChIKey=TZFUBYYADABEAV-UHFFFAOYSA-N

InChI=1S/C17H19N3O/c21-17(16-8-4-5-9-18-16)20-12-10-19(11-13-20)14-15-6-2-1-3-7-15/h1-9H,10-14H2

HIDE SMILES / InChI

Molecular Formula	C17H19N3O
Molecular Weight	281.3523
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800000657 | https://www.ncbi.nlm.nih.gov/pubmed/7389821 | https://www.ncbi.nlm.nih.gov/pubmed/6667064 | https://www.ncbi.nlm.nih.gov/pubmed/2448760

Piberaline (EGYT-475) is the antidepressant drug. Piberaline antagonized the reserpine-induced dopamine depletion in the olfactory tubercle of rats. Piberaline in contrast to tricyclic antidepressants does not impair the acquisition of avoidance conditioning but rather improves it while it does not facilitate the extinction of learned behavior but considerably delays it. EGYT-2760, an active metabolite of EGYT-475, has a central serotoninomimetic action which involves 5-HT uptake-inhibition and 5-HT1 receptor agonistic effect.

Originator

Approval Year

PubMed

Title	Date	PubMed
Studies on the biochemical mode of action of EGYT-475, a new antidepressant.	1987 Mar-Apr	2448760
Comparison of serotonin agonistic and antagonistic activities of a new antidepressant agent Trelibet (EGYT-475) and its metabolite EGYT-2760 on isolated rat fundus.	1991	1814162

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:04:33 GMT 2023` Edited by `admin` on `Sat Dec 16 16:04:33 GMT 2023`
Record UNII	8M09P36809
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIBERALINE

Official Name

English

piberaline [INN]

Common Name

English

PIBERALINE [MI]

Common Name

English

1-BENZYL-4-PICOLINOYLPIPERAZINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265