Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C33H52O8 |
Molecular Weight | 576.7612 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 16 / 16 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2)O[C@]7([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O
InChI
InChIKey=WXMARHKAXWRNDM-GAMIEDRGSA-N
InChI=1S/C33H52O8/c1-17-7-12-33(38-16-17)18(2)26-24(41-33)14-23-21-6-5-19-13-20(8-10-31(19,3)22(21)9-11-32(23,26)4)39-30-29(37)28(36)27(35)25(15-34)40-30/h5,17-18,20-30,34-37H,6-16H2,1-4H3/t17-,18+,20+,21-,22+,23+,24+,25-,26+,27-,28+,29-,30-,31+,32+,33-/m1/s1
Molecular Formula | C33H52O8 |
Molecular Weight | 576.7612 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 15 / 16 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Disogluside (Trillin) is an active ingredient isolated from Dioscorea nipponica Makino. Trillin reduces liver chronic inflammation and fibrosis in carbon tetrachloride (CCl4) induced liver injury in mice. Trillin exhibited protective effect on LPS-induced ALI by the regulations of related inflammatory events via the activations of Nrf2, HO-1 and NF-κB pathway. Trillin has being shown to exert protective effects against hyperlipidemia and oxidative stress. Trillin induced
multinucleation in HL-60, NB4 and K562 cells, indicating
it could induce mitotic arrest in these leukemia cells.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0006954 |
|||
Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15256740 |
7.5 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27219527
Mice: Disogluside (Trillin) (50 mg/kg, 100 mg/kg) was administered by gavage for 12 days before finishing the CCl4 induction.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15256740
Disogluside (Trillin) inhibited proliferation of K562 cells with IC50 value of 7.5 uM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:03:51 GMT 2023
by
admin
on
Fri Dec 15 16:03:51 GMT 2023
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Record UNII |
8KI671F2NS
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C29703
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8KI671F2NS
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C78057
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74020
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CHEMBL395414
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SUB07236MIG
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11827970
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5166
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14144-06-0
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Related Record | Type | Details | ||
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ACTIVE MOIETY |