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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H13NO4
Molecular Weight 211.2145
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYLDOPA, D-

SMILES

C[C@@](N)(CC1=CC=C(O)C(O)=C1)C(O)=O

InChI

InChIKey=CJCSPKMFHVPWAR-SNVBAGLBSA-N
InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H13NO4
Molecular Weight 211.2145
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

D-Methyldopa is an inactive isomer of methyldopa. It is known, that only L-isomer has the ability to inhibit dopa decarboxylase and possesses the antihypertensive activity in man. Moreover, about twice the dose of the racemate (DL-form of methyldopa) is required for the equal antihypertensive effect.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:04:59 UTC 2023
Edited
by admin
on Sat Dec 16 08:04:59 UTC 2023
Record UNII
8K91SZC8W9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METHYLDOPA, D-
Common Name English
D-.ALPHA.-METHYLDOPA
Common Name English
D-(3,4-DIHYDROXYPHENYL)-2-METHYLALANINE
Common Name English
METHYLDOPA ANHYDROUS, D-
Common Name English
D-TYROSINE, 3-HYDROXY-.ALPHA.-METHYL-
Systematic Name English
D-METHYLDOPA
Common Name English
(2R)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPANOIC ACID
Systematic Name English
IMT-002
Code English
METHYLDOPA IMPURITY D [EP IMPURITY]
Common Name English
(+)-.ALPHA.-METHYLDOPA
Common Name English
D-.ALPHA.-METHYL-3-(3,4-DIHYDROXYPHENYL)ALANINE
Common Name English
Code System Code Type Description
CLINICAL_TRIALS.GOV
NCT00976235
Created by admin on Sat Dec 16 08:04:59 UTC 2023 , Edited by admin on Sat Dec 16 08:04:59 UTC 2023
PRIMARY
EPA CompTox
DTXSID50859484
Created by admin on Sat Dec 16 08:04:59 UTC 2023 , Edited by admin on Sat Dec 16 08:04:59 UTC 2023
PRIMARY
FDA UNII
8K91SZC8W9
Created by admin on Sat Dec 16 08:04:59 UTC 2023 , Edited by admin on Sat Dec 16 08:04:59 UTC 2023
PRIMARY
CAS
2799-15-7
Created by admin on Sat Dec 16 08:04:59 UTC 2023 , Edited by admin on Sat Dec 16 08:04:59 UTC 2023
PRIMARY
PUBCHEM
721860
Created by admin on Sat Dec 16 08:04:59 UTC 2023 , Edited by admin on Sat Dec 16 08:04:59 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY
IMT-002 (D-MDOPA) is an oral small molecule drug being developed to treat T1D in patients with the HLA-DQ8 gene. When HLA-DQ8 function is inhibited, the immune system will no longer attack insulin producing beta-cells,