| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H25NO |
| Molecular Weight | 223.3544 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC\C=C\C=C\C(=O)NCC(C)C
InChI
InChIKey=MAGQQZHFHJDIRE-BNFZFUHLSA-N
InChI=1S/C14H25NO/c1-4-5-6-7-8-9-10-11-14(16)15-12-13(2)3/h8-11,13H,4-7,12H2,1-3H3,(H,15,16)/b9-8+,11-10+
| Molecular Formula | C14H25NO |
| Molecular Weight | 223.3544 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Optical Activity | NONE |
Pellitorine is a major amide alkaloid, isolated from Piper longum, Zanthoxylum piperitum or heitzii, Anacyclus pyrethrum, Piper nigrum. Pellitorine can serve as an antagonist of the TRPV1 and may inhibit exovanilloid-induced pain. It exhibits anti-inflammatory activity via activating the Nrf2/HO-1 pathway. Pellitorine shows a good gut permeation and rapidly permeates the BBB once in the blood, indicating a possible role in the treatment of central nervous system diseases. Pellitorine, which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cancer cell lines. The drug possesses antithrombotic activities and offers bases for development of a novel anticoagulant.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antifungal and antioxidant compounds from the root bark of Fagara zanthoxyloides. | 2003 Apr |
Sample Use Guides
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
1587 | PRIMARY | |||
|
18836-52-7 | PRIMARY | |||
|
DTXSID301019978 | PRIMARY | |||
|
C008778 | PRIMARY | |||
|
8IS5231171 | PRIMARY | |||
|
5318516 | PRIMARY | |||
|
m8452 | PRIMARY | Merck Index |