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Details

Stereochemistry ACHIRAL
Molecular Formula C19H22F3N3
Molecular Weight 349.3933
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LY-165163

SMILES

NC1=CC=C(CCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)C=C1

InChI

InChIKey=GAAKALASJNGQKD-UHFFFAOYSA-N
InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

HIDE SMILES / InChI
Molecular Formula C19H22F3N3
Molecular Weight 349.3933
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

LY-165163 is a partial agonist of serotonin receptors 5-HT1A and 5-HT1D. It exhibits marked activity at both pre- and postsynaptic dopaminergic D2 (D3 and D1) receptors. LY-165163 caused a significant and dose-dependent hypothermia in rats. As a 5-HT1D receptor agonist, LY-165163 was proposed for the ocular pain treatment.

CNS Activity

Originator

Eli Lilly
237
Curator's Comment: # Eli Lilly and Co.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Partial Agonist
290
 8.9 null [pKi]
Antagonist
2778
 7.2 null [pKi]
Antagonist
2778
 7.8 null [pKi]
Antagonist
2778
 5.7 null [pKi]
5-hydroxytryptamine receptor 1D
17
Target ID: P11614
Gene ID: 403963.0
Gene Symbol: HTR1D
Target Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Partial Agonist
290
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Not Provided
504
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
1993 Mar
Patents

Patents

CA2666036C
1
US20150315575
1
WO1997044062A1
2

Sample Use Guides

In Vivo Use Guide
Rat: 1.25 to 20 mg/kg
Route of Administration: Intraperitoneal
In Vitro Use Guide
With either 10 microM 5-HT or 1 microM 8-hydroxy-2-(di-n-propylamino)tetralin to define nonspecific binding, [3H]PAPP bound to a single class of sites in rat cortical membranes with a KD of 1.6 nM and a maximal binding density (Bmax) of 162 fmol/mg of protein.
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:07:53 GMT 2023
Edited
by admin
on Fri Dec 15 18:07:53 GMT 2023
Record UNII
8HAJ699EWG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LY-165163
Common Name English
BENZENAMINE, 4-(2-(4-(3-(TRIFLUOROMETHYL)PHENYL)-1-PIPERAZINYL)ETHYL)-
Systematic Name English
P-NH2-PE-TFMPP
Common Name English
Code System Code Type Description
PUBCHEM
121930
Created by admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
PRIMARY
FDA UNII
8HAJ699EWG
Created by admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
PRIMARY
CAS
1814-64-8
Created by admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
PRIMARY
EPA CompTox
DTXSID30171136
Created by admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
PRIMARY
Related Record Type Details
Structure of LY-165163
ACTIVE MOIETY
NIH
NCATS
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