U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Body protective compound – 15 also known as bepecin, BPC 157 or PL 14736, a small, chemically synthesized pentadecapeptide which has been shown to be safe in clinical trials for inflammatory bowel disease and may be able to cure intestinal anastomosis dehiscence. BPC 157 also was involved in phase I development in Ulcerative colitis, however, no reports of development identified. Recently published article has described that BPC 157 had huge potential as a therapy to conservatively treat or aid recovery in hypovascular and hypocellular soft tissues such as tendon and ligaments. Although is still a need to understand the precise healing mechanisms for this therapy to achieve clinical realization.

Approval Year

PubMed

PubMed

TitleDatePubMed
Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine.
2001 Jan-Dec

Sample Use Guides

Single dose of 1 oral tablet of PCO-02 containing 1 mg of Bepecin (12 subjects). Phase 1a: Healthy volunteers will take a single dose of 1, 3 or 6 tablets by mouth of PCO-02 containing 1 mg of Bepecin to study safety and pharmacokinetics. Phase 1b: All subjects will take 3 tablets of PCO-02 containing 1 mg of Bepecin every 8 hours during two weeks, to study safety and pharmacokinetics.
Route of Administration: Oral
Substance Class Protein
Created
by admin
on Sat Dec 16 20:08:15 GMT 2023
Edited
by admin
on Sat Dec 16 20:08:15 GMT 2023
Protein Sub Type
Record UNII
8ED8NXK95P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BPC-157
Common Name English
PL-14736
Code English
L-Valine, glycyl-L-α-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-α-aspartyl-L-α-aspartyl-L-alanylglycyl-L-leucyl-
Systematic Name English
BEPECIN
Common Name English
PL-10
Code English
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Systematic Name English
PLD-116
Code English
Code System Code Type Description
PUBCHEM
9941957
Created by admin on Sat Dec 16 20:08:15 GMT 2023 , Edited by admin on Sat Dec 16 20:08:15 GMT 2023
PRIMARY
WIKIPEDIA
BPC-157
Created by admin on Sat Dec 16 20:08:15 GMT 2023 , Edited by admin on Sat Dec 16 20:08:15 GMT 2023
PRIMARY
FDA UNII
8ED8NXK95P
Created by admin on Sat Dec 16 20:08:15 GMT 2023 , Edited by admin on Sat Dec 16 20:08:15 GMT 2023
PRIMARY
CAS
137525-51-0
Created by admin on Sat Dec 16 20:08:15 GMT 2023 , Edited by admin on Sat Dec 16 20:08:15 GMT 2023
PRIMARY
DRUG BANK
DB11882
Created by admin on Sat Dec 16 20:08:15 GMT 2023 , Edited by admin on Sat Dec 16 20:08:15 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL