Efbalropendekin Alfa

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 04:10:58 GMT 2025` Edited by `admin` on `Wed Apr 02 04:10:58 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	INTERLEUKINS
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8DQ4YVG4D5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Efbalropendekin Alfa

Official Name

English

Interleukin 15 [30-asparagine,64-glutamine,65-aspartic acid] (human) fusion protein with peptide linker (GGGGS) fusion protein with immunoglobulin G1 [4-serine,18-proline,19-valine,20-alanine,51-lysine,79-glutamic acid,140-glutamic acid,142-methionine,15

Preferred Name

English

human interleukin-15 (IL-15) fragment (1-114) variant (D<sup>30</sup>>N, E<sup>64</sup>>Q, N<sup>65</sup>>D) fused via peptide linker <sup>115</sup>GGGGS<sup>119</sup> to a human immunoglobulin G1 C-terminal Fc fragment (120-350) variant, [Homo sapiens I

Common Name

English

efbalropendekin alfa [INN]

Common Name

English

Code System Code Type Description

FDA UNII

8DQ4YVG4D5

Created by admin on Wed Apr 02 04:10:58 GMT 2025 , Edited by admin on Wed Apr 02 04:10:58 GMT 2025

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SMS_ID

300000025418

Created by admin on Wed Apr 02 04:10:58 GMT 2025 , Edited by admin on Wed Apr 02 04:10:58 GMT 2025

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INN

12475

Created by admin on Wed Apr 02 04:10:58 GMT 2025 , Edited by admin on Wed Apr 02 04:10:58 GMT 2025

PRIMARY

CAS

2736449-62-8

Created by admin on Wed Apr 02 04:10:58 GMT 2025 , Edited by admin on Wed Apr 02 04:10:58 GMT 2025

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NCI_THESAURUS

C199034

Created by admin on Wed Apr 02 04:10:58 GMT 2025 , Edited by admin on Wed Apr 02 04:10:58 GMT 2025

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From	To
1_35	1_85
1_42	1_88
1_130	2_81
1_133	2_84
1_164	1_224
1_270	1_328
2_3	2_45
2_29	2_63
2_115	2_175
2_221	2_279

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_71
N	1_79
N	1_112
N	1_200
N	2_151
O	2_2

Related Record Type Details


					8DQ4YVG4D5

Efbalropendekin Alfa

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_350] [2_301]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL