Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H11O7.Na |
| Molecular Weight | 218.1371 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O
InChI
InChIKey=UPMFZISCCZSDND-JSCKKFHOSA-M
InChI=1S/C6H12O7.Na/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3+,4-,5-;/m0./s1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H11O7 |
| Molecular Weight | 195.1473 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
L-Gulonic acid, a diastereomer of d-gluconic acid is the one of a metabolite in the urinate cycle, is a substrate of L-Gulonate 3-dehydrogenase (GDH). This enzyme catalyzes the NAD(+)-linked dehydrogenation of L-gulonate into dehydro-L-gulonate. L-Gulonic acid is also a metabolite of the D-glucuronic acid pathway. It was suggested, that the measurement of a spectrum of urinary D-glucuronic acid metabolites might provide a more reliable index for assessment of the induction of hepatic xenobiotic-metabolizing enzyme activities in man than the determination of urinary D-glucaric acid alone.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. | 2005 Jul |
|
| Crystallization and preliminary X-ray crystallographic analysis of rabbit L-gulonate 3-dehydrogenase. | 2008 Mar 1 |
|
| Dimeric crystal structure of rabbit L-gulonate 3-dehydrogenase/lambda-crystallin: insights into the catalytic mechanism. | 2010 Sep 3 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:23:16 GMT 2023
by
admin
on
Sat Dec 16 08:23:16 GMT 2023
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| Record UNII |
8DNN0PFW0V
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| Record Status |
Validated (UNII)
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| Record Version |
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90479684
Created by
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6027-87-8
Created by
admin on Sat Dec 16 08:23:16 GMT 2023 , Edited by admin on Sat Dec 16 08:23:16 GMT 2023
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8DNN0PFW0V
Created by
admin on Sat Dec 16 08:23:16 GMT 2023 , Edited by admin on Sat Dec 16 08:23:16 GMT 2023
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m5882
Created by
admin on Sat Dec 16 08:23:16 GMT 2023 , Edited by admin on Sat Dec 16 08:23:16 GMT 2023
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PRIMARY | Merck Index |