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Details

Stereochemistry ACHIRAL
Molecular Formula C9H13NO2
Molecular Weight 167.205
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYRITHYLDIONE

SMILES

CCC1(CC)C(=O)NC=CC1=O

InChI

InChIKey=NZASCBIBXNPDMH-UHFFFAOYSA-N
InChI=1S/C9H13NO2/c1-3-9(4-2)7(11)5-6-10-8(9)12/h5-6H,3-4H2,1-2H3,(H,10,12)

HIDE SMILES / InChI

Molecular Formula C9H13NO2
Molecular Weight 167.205
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pyrithyldione is a sedative and hypnotic drug. It was demonstrated that drug has certain advantages over the barbiturates. It was indicated in mild cases of insomnia and in small doses as a sedative agent during the day. Pyrithyldione was withdrawn from the marked due to several cases of agranulocytosis.

CNS Activity

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Persedon
Primary
Persedon

T1/2

ValueDoseCo-administeredAnalytePopulation
14.5 h
single, oral
PYRITHYLDIONE plasma
Homo sapiens

Doses

AEs

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

PubMed

Sample Use Guides

In Vivo Use Guide
0.2-0.4 g (1-2 tablets) 15-20 minutes before going to bed
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
8AB20823CK
Record Status Validated (UNII)
Record Version