Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C9H10FN3O4 |
Molecular Weight | 243.1918 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12OC3=NC(=N)C(F)=C[N@]3[C@]1([H])O[C@H](CO)[C@H]2O
InChI
InChIKey=PAYBYKKERMGTSS-MNCSTQPFSA-N
InChI=1S/C9H10FN3O4/c10-3-1-13-8-6(5(15)4(2-14)16-8)17-9(13)12-7(3)11/h1,4-6,8,11,14-15H,2H2/t4-,5-,6+,8-/m1/s1
Molecular Formula | C9H10FN3O4 |
Molecular Weight | 243.1918 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/1149046Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/348088
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1149046
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/348088
Flurocitabine is an anti-metabolite that was developed by Hoffmann-La Roche for the treatment of cancer. The drug is metabolized to 2 biologically active substances, AFC (1-beta-D-arabinofuranosyl-5-fluorocytosine) and AFU (arabinofuranosyl-5-fluorouracil). Flurocitabine was tested against stomach cancer, pancreatic cancer, small cell lung cancer and AML, however, the development was terminated in the early phases.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1149046
Curator's Comment: # Hoffmann-La Roche Ltd
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/93030
Curator's Comment: http://ascopubs.org/doi/pdf/10.1200/jco.1992.10.3.484
The maximum tolerated dose is 650 mg/m2 I.V. weekly (stomach cancer). In acute nonlymphocytic leukemia the dose is 800 mg/m2 (600mg/m2 in children) given every 12 hours until marrow hypocellularity is achieved. In Small-Cell Lung Cancer the dose is 15-20 mg/m2 IV given daily for 5 days every 3 weeks or 33-40 mg/m2 IV given weekly.
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:41:16 GMT 2023
by
admin
on
Sat Dec 16 17:41:16 GMT 2023
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Record UNII |
89TPE33M27
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C1557
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37717-21-8
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89TPE33M27
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100000080931
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4335
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3034016
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C2343
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253-638-9
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C011168
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SUB07748MIG
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CHEMBL472561
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DTXSID401317496
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