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Details

Stereochemistry ACHIRAL
Molecular Formula C13H11NO3
Molecular Weight 229.2313
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OSALMID

SMILES

OC1=CC=C(NC(=O)C2=CC=CC=C2O)C=C1

InChI

InChIKey=LGCMKPRGGJRYGM-UHFFFAOYSA-N
InChI=1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)

HIDE SMILES / InChI

Molecular Formula C13H11NO3
Molecular Weight 229.2313
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Osalmid (Oxaphenamide) is a choleretic drug. It is also recommended for use as a choleretic, principally in combination with antibiotics, in the convalescent stage of infectious hepatitis.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
8.23 µM [IC50]
11.1 µM [EC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Palliative
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Tablets of 0.25 - 0.5 g three times a day before meals. The course of treatment, on average, 15 to 20 days
Route of Administration: Oral
In Vitro Use Guide
After treatment for 8d, the 50% effective concentrations of osalmid (EC50) for HBV DNA inhibition were 11.1 uM for culture supernatant and 16.5 uM for HepG2.2.15 cells, as determined by Q-PCR
Substance Class Chemical
Record UNII
89741L759Z
Record Status Validated (UNII)
Record Version