Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H27FN2O4 |
| Molecular Weight | 414.4699 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=C(C)C=C(C(=O)NC2(CCCCC2)C(O)=O)C(=O)N1CC3=CC=C(F)C=C3
InChI
InChIKey=JIYXOJFSPOFZPY-UHFFFAOYSA-N
InChI=1S/C23H27FN2O4/c1-3-19-15(2)13-18(20(27)25-23(22(29)30)11-5-4-6-12-23)21(28)26(19)14-16-7-9-17(24)10-8-16/h7-10,13H,3-6,11-12,14H2,1-2H3,(H,25,27)(H,29,30)
| Molecular Formula | C23H27FN2O4 |
| Molecular Weight | 414.4699 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Shionogi developed S 777469 as a selective cannabinoid 2 receptor agonist for the atopic dermatitis treatment. This drug successfully completed phase II clinical trial, where was evaluate its safety and efficacy in patients with atopic dermatitis. However, information about the further development of S 777469 is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent. | 2012 Apr 15 |
|
| S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission. | 2015 |
|
| The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice. | 2017 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:19:28 UTC 2023
by
admin
on
Fri Dec 15 16:19:28 UTC 2023
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| Record UNII |
88NI79737I
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| Record Status |
Validated (UNII)
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| Record Version |
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57331749
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S-777,469
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88NI79737I
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DTXSID301336647
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885496-53-7
Created by
admin on Fri Dec 15 16:19:28 UTC 2023 , Edited by admin on Fri Dec 15 16:19:28 UTC 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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METABOLITE INACTIVE -> PARENT |
MAJOR
FECAL; PLASMA; URINE
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
