Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H27FN2O4 |
| Molecular Weight | 414.4699 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=C(C)C=C(C(=O)NC2(CCCCC2)C(O)=O)C(=O)N1CC3=CC=C(F)C=C3
InChI
InChIKey=JIYXOJFSPOFZPY-UHFFFAOYSA-N
InChI=1S/C23H27FN2O4/c1-3-19-15(2)13-18(20(27)25-23(22(29)30)11-5-4-6-12-23)21(28)26(19)14-16-7-9-17(24)10-8-16/h7-10,13H,3-6,11-12,14H2,1-2H3,(H,25,27)(H,29,30)
| Molecular Formula | C23H27FN2O4 |
| Molecular Weight | 414.4699 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Shionogi developed S 777469 as a selective cannabinoid 2 receptor agonist for the atopic dermatitis treatment. This drug successfully completed phase II clinical trial, where was evaluate its safety and efficacy in patients with atopic dermatitis. However, information about the further development of S 777469 is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice. | 2017 |
|
| S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission. | 2015 |
|
| Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent. | 2012-04-15 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:25:06 GMT 2025
by
admin
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Mon Mar 31 18:25:06 GMT 2025
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| Record UNII |
88NI79737I
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| Record Status |
Validated (UNII)
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| Record Version |
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S-777,469
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88NI79737I
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DTXSID301336647
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885496-53-7
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| Related Record | Type | Details | ||
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METABOLITE INACTIVE -> PARENT |
MAJOR
FECAL; PLASMA; URINE
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ACTIVE MOIETY |
