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Details

Stereochemistry ACHIRAL
Molecular Formula C24H30O2S
Molecular Weight 382.559
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SUMAROTENE

SMILES

C\C(=C/C1=CC=C(C=C1)S(C)(=O)=O)C2=CC3=C(C=C2)C(C)(C)CCC3(C)C

InChI

InChIKey=AUCWKKVIBKHRED-BMRADRMJSA-N
InChI=1S/C24H30O2S/c1-17(15-18-7-10-20(11-8-18)27(6,25)26)19-9-12-21-22(16-19)24(4,5)14-13-23(21,2)3/h7-12,15-16H,13-14H2,1-6H3/b17-15+

HIDE SMILES / InChI

Molecular Formula C24H30O2S
Molecular Weight 382.559
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Sumarotene (also known as Ro 14-9706) is a third-generation retinoid developed by Hoffmann-La Roche, F., und Co. A.-G., as a topical dermatologic agent for the repair of photodamage, antikeratinization, and antiproliferation. Sumarotene shows activity in standard preclinical and pharmacologic models of repair of photodamage, antikeratinization, and antiproliferation. In clinical trials, Sumarotene effectively decreases the number of actinic keratoses. Sumarotene is well-tolerated and most patients have only slight or absent local inflammation.

Approval Year

PubMed

PubMed

TitleDatePubMed
Topical treatment of multiple actinic keratoses of the face with arotinoid methyl sulfone (Ro 14-9706) cream versus tretinoin cream: a double-blind, comparative study.
1991 Mar
Patents

Patents

Sample Use Guides

twice daily for 16 weeks as a 0.05% cream
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:46:55 GMT 2023
Edited
by admin
on Fri Dec 15 15:46:55 GMT 2023
Record UNII
8896RX4S4J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SUMAROTENE
INN   USAN  
USAN   INN  
Official Name English
sumarotene [INN]
Common Name English
SUMAROTENE [USAN]
Common Name English
RO 14-9706/000
Code English
RO-14-9706/000
Code English
RO-149706000
Code English
Classification Tree Code System Code
NCI_THESAURUS C938
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
Code System Code Type Description
SMS_ID
100000082981
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
CAS
105687-93-2
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
EVMPD
SUB10769MIG
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
EPA CompTox
DTXSID10883164
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
FDA UNII
8896RX4S4J
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
INN
6738
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105526
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
NCI_THESAURUS
C74431
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
USAN
CC-38
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
PUBCHEM
6436127
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
MESH
C069613
Created by admin on Fri Dec 15 15:46:55 GMT 2023 , Edited by admin on Fri Dec 15 15:46:55 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY