INCB-057643

Investigational

CN1C=C(C2=C(NC=C2)C1=O)C3=CC(=CC4=C3OC(C)(C)C(=O)N4C)S(C)(=O)=O

InChIKey=VZSAMEOETVNDQH-UHFFFAOYSA-N

InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24)16-12(14)6-7-21-16/h6-10,21H,1-5H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Bromodomain-containing protein 2 7 Target ID: CHEMBL1293289 Sources: http://cancerres.aacrjournals.org/content/77/13_Supplement/5071	Inhibitor 8504
Bromodomain-containing protein 4 13 Target ID: CHEMBL1163125 Sources: http://cancerres.aacrjournals.org/content/77/13_Supplement/5071	Inhibitor 8504
Bromodomain-containing protein 3 7 Target ID: CHEMBL1795186 Sources: http://cancerres.aacrjournals.org/content/77/13_Supplement/5071	Inhibitor 8504

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:29:51 GMT 2025` Edited by `admin` on `Tue Apr 01 16:29:51 GMT 2025`
Record UNII	87TZD0JEBS
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

INCB-057643

Common Name

English

INCB057643

Preferred Name

English

2,2,4-TRIMETHYL-8-(6-METHYL-7-OXO-6,7-DIHYDRO-1H-PYRROLO(2,3-C)PYRIDIN-4-YL)-6-(METHYLSULFONYL)-2H-BENZO(B)(1,4)OXAZIN-3(4H)-ONE

Systematic Name

English

2H-1,4-BENZOXAZIN-3(4H)-ONE, 8-(6,7-DIHYDRO-6-METHYL-7-OXO-1H-PYRROLO(2,3-C)PYRIDIN-4-YL)-2,2,4-TRIMETHYL-6-(METHYLSULFONYL)-

Systematic Name

English

Code System Code Type Description

NCI_THESAURUS

C128622