1-(2-(4-(6-FLUORO-1,2-BENZOXAZOL-3-YL)-1-PIPERIDYL)ETHYL)-3-PHENYL-IMIDAZOLIDIN-2-ONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H25FN4O2
Molecular Weight	408.4686
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 1-(2-(4-(6-FLUORO-1,2-BENZOXAZOL-3-YL)-1-PIPERIDYL)ETHYL)-3-PHENYL-IMIDAZOLIDIN-2-ONE

Structure Search

SMILES

FC1=CC2=C(C=C1)C(=NO2)C3CCN(CCN4CCN(C4=O)C5=CC=CC=C5)CC3

InChI

InChIKey=ULCAXFRFGIKHRG-UHFFFAOYSA-N

InChI=1S/C23H25FN4O2/c24-18-6-7-20-21(16-18)30-25-22(20)17-8-10-26(11-9-17)12-13-27-14-15-28(23(27)29)19-4-2-1-3-5-19/h1-7,16-17H,8-15H2

HIDE SMILES / InChI

Molecular Formula	C23H25FN4O2
Molecular Weight	408.4686
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.	2009-07	19326101

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:53:49 GMT 2025` Edited by `admin` on `Mon Mar 31 20:53:49 GMT 2025`
Record UNII	879Y6TC7CG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

S-18327

Preferred Name

English

1-(2-(4-(6-FLUORO-1,2-BENZOXAZOL-3-YL)-1-PIPERIDYL)ETHYL)-3-PHENYL-IMIDAZOLIDIN-2-ONE

Systematic Name

English

S18327

Code

English

2-IMIDAZOLIDINONE, 1-(2-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL)ETHYL)-3-PHENYL-

Systematic Name

English

Code System Code Type Description

FDA UNII

879Y6TC7CG

Created by admin on Mon Mar 31 20:53:49 GMT 2025 , Edited by admin on Mon Mar 31 20:53:49 GMT 2025

PRIMARY

PUBCHEM

9953269

Created by admin on Mon Mar 31 20:53:49 GMT 2025 , Edited by admin on Mon Mar 31 20:53:49 GMT 2025

PRIMARY

CAS

200398-40-9

Created by admin on Mon Mar 31 20:53:49 GMT 2025 , Edited by admin on Mon Mar 31 20:53:49 GMT 2025

PRIMARY

EPA CompTox

DTXSID30433286

Created by admin on Mon Mar 31 20:53:49 GMT 2025 , Edited by admin on Mon Mar 31 20:53:49 GMT 2025

PRIMARY

Related Record Type Details


					879Y6TC7CG

1-(2-(4-(6-FLUORO-1,2-BENZOXAZOL-3-YL)-1-PIPERIDYL)ETHYL)-3-PHENYL-IMIDAZOLIDIN-2-ONE

ACTIVE MOIETY

Comments:

Relative to the above paradigms, only markedly (>20-fold) higher doses of S18327 were active in models predictive of potential extrapyramidal side effects: induction of catalepsy and prolactin secretion, and inhibition of methylphenidate-induced gnawing in rats.