NIFENAZONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16N4O2
Molecular Weight	308.3345
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1N(C(=O)C(NC(=O)C2=CC=CN=C2)=C1C)C3=CC=CC=C3

InChI

InChIKey=BRZANEXCSZCZCI-UHFFFAOYSA-N

InChI=1S/C17H16N4O2/c1-12-15(19-16(22)13-7-6-10-18-11-13)17(23)21(20(12)2)14-8-4-3-5-9-14/h3-11H,1-2H3,(H,19,22)

HIDE SMILES / InChI

Molecular Formula	C17H16N4O2
Molecular Weight	308.3345
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14133613
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24954054

Nifenazone is a drug that has been used as an analgesic for a number of rheumatic conditions. Later it was shown that nifenazone is not of significant value in the therapy of the chronic rheumatic disorders and that side-effects may be expected to occur, particularly in those patients who give a history of abnormal reactions to phenylbutazone and oxyphenbutazone.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatic disorders 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14133613	Palliative		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study.	2014-08-07	24954054
Evaluation of liver function during administration of nifenazone in rheumatic disease on the basis of serum protein studies and enzyme tests.	1972-04-01	4270064
TRIAL OF NIFENAZONE ("THYLIN").	1964-06-13	14133613

Patents

Sample Use Guides

In Vivo Use Guide

750 - 2,000 mg. daily, orally in divided dosage.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:49 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:49 GMT 2025`
Record UNII	8780F0K71U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NIAPYRIN

Preferred Name

English

NIFENAZONE

Official Name

English

NIFENAZONE [MART.]

Common Name

English

NIFENAZONE [MI]

Common Name

English

N-ANTIPYRINYLNICOTINAMIDE

Common Name

English

NIFENAZONE [JAN]

Common Name

English

NICOPHEZON

Brand Name

English

nifenazone [INN]

Common Name

English

Nifenazone [WHO-DD]

Common Name

English

NSC-758411

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C257