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Details

Stereochemistry ACHIRAL
Molecular Formula C17H16N4O2
Molecular Weight 308.3345
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIFENAZONE

SMILES

CN1N(C(=O)C(NC(=O)C2=CN=CC=C2)=C1C)C3=CC=CC=C3

InChI

InChIKey=BRZANEXCSZCZCI-UHFFFAOYSA-N
InChI=1S/C17H16N4O2/c1-12-15(19-16(22)13-7-6-10-18-11-13)17(23)21(20(12)2)14-8-4-3-5-9-14/h3-11H,1-2H3,(H,19,22)

HIDE SMILES / InChI
Molecular Formula C17H16N4O2
Molecular Weight 308.3345
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24954054

Nifenazone is a drug that has been used as an analgesic for a number of rheumatic conditions. Later it was shown that nifenazone is not of significant value in the therapy of the chronic rheumatic disorders and that side-effects may be expected to occur, particularly in those patients who give a history of abnormal reactions to phenylbutazone and oxyphenbutazone.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
TRIAL OF NIFENAZONE ("THYLIN").
1964 Jun 13
The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study.
2014 Aug 7
Patents

Patents

US2015374703
2
US2016016916
3
US7718441
2

Sample Use Guides

In Vivo Use Guide
750 - 2,000 mg. daily, orally in divided dosage.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:57:55 UTC 2023
Edited
by admin
on Fri Dec 15 15:57:55 UTC 2023
Record UNII
8780F0K71U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NIFENAZONE
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
NIAPYRIN
Brand Name English
NIFENAZONE [MART.]
Common Name English
NIFENAZONE [MI]
Common Name English
N-ANTIPYRINYLNICOTINAMIDE
Common Name English
NIFENAZONE [JAN]
Common Name English
NICOPHEZON
Brand Name English
nifenazone [INN]
Common Name English
Nifenazone [WHO-DD]
Common Name English
NSC-758411
Code English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
WHO-VATC QM02AA24
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
WHO-ATC N02BB05
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
WHO-ATC M02AA24
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
WHO-VATC QN02BB05
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
Code System Code Type Description
CAS
2139-47-1
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
MERCK INDEX
m368
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY Merck Index
PUBCHEM
4487
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
EVMPD
SUB09256MIG
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
NSC
758411
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
MESH
C005249
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
SMS_ID
100000084422
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
FDA UNII
8780F0K71U
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
ChEMBL
CHEMBL1413176
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
ECHA (EC/EINECS)
218-387-1
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
WIKIPEDIA
Nifenazone
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
NCI_THESAURUS
C76806
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
INN
1834
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
EPA CompTox
DTXSID7045366
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
DRUG BANK
DB13407
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
DRUG CENTRAL
1924
Created by admin on Fri Dec 15 15:57:55 UTC 2023 , Edited by admin on Fri Dec 15 15:57:55 UTC 2023
PRIMARY
Related Record Type Details
Structure of NIFENAZONE DIHYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of NIFENAZONE
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