Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C44H64O24 |
Molecular Weight | 976.9646 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 20 / 20 |
E/Z Centers | 7 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(\C=C\C=C(/C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)=C/C=C/C=C(C)/C=C/C=C(\C)C(=O)O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O
InChI
InChIKey=SEBIKDIMAPSUBY-RTJKDTQDSA-N
InChI=1S/C44H64O24/c1-19(11-7-13-21(3)39(59)67-43-37(57)33(53)29(49)25(65-43)17-61-41-35(55)31(51)27(47)23(15-45)63-41)9-5-6-10-20(2)12-8-14-22(4)40(60)68-44-38(58)34(54)30(50)26(66-44)18-62-42-36(56)32(52)28(48)24(16-46)64-42/h5-14,23-38,41-58H,15-18H2,1-4H3/b6-5+,11-7+,12-8+,19-9+,20-10+,21-13+,22-14+/t23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33+,34+,35-,36-,37-,38-,41-,42-,43+,44+/m1/s1
Molecular Formula | C44H64O24 |
Molecular Weight | 976.9646 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 20 / 20 |
E/Z Centers | 7 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/24275090Curator's Comment: Description was created based on several sources, including
http://iglobaljournal.com/wp-content/uploads/2012/01/1.-Singla-Bhat-2011.pdf |
http://saffronhealthsci.com/product/ | https://www.ncbi.nlm.nih.gov/pubmed/24393168
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24275090
Curator's Comment: Description was created based on several sources, including
http://iglobaljournal.com/wp-content/uploads/2012/01/1.-Singla-Bhat-2011.pdf |
http://saffronhealthsci.com/product/ | https://www.ncbi.nlm.nih.gov/pubmed/24393168
Crocin is the chemical constituent isolated from the Saffron, the dried trifid stigma of the plant Crocus sativus L. and also from the fruits of Gardenia(Gardenia jasminoides Ellis) Of the carotenoids present in saffron, highly water-soluble crocin (mono and diglycosyl esters of a polyene dicarboxylic acid, named crocetin) is responsible for the majority of its color, and appears to possess various health-promoting properties, as an antioxidant, antitumor, memory enhancer, antidepressant, anxiolytic and aphrodisiac. It is also worth noting that the crocin principle of saffron exhibited high efficacy along with no major toxicity in experimental models. A proteomic study revealed that crocin physically binds to a wide range of cellular proteins such as structural proteins, membrane transporters, and enzymes involved in ATP and redox homeostasis and signal transduction. CROCIN RICH products provide highly purified natural crocin as dietary supplements, they are the purest and most effective formulation of crocin available.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10815004 | https://www.ncbi.nlm.nih.gov/pubmed/26468457
Curator's Comment: Crocin is CNS active in animals. No human data available however as a constituent of saffron (Crocus sativus L.) crocin may be responsible for its antidepressant action
https://www.ncbi.nlm.nih.gov/pubmed/15341662
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2095182 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28337976 |
|||
Target ID: CHEMBL1973 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26187443 |
56.0 µM [Kd] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: http://saffronhealthsci.com/product/crocin-rich-ii/
Crocin as dietary supplement (each tablet provides crocin equivalent to 275mg of top grade saffron): Take one tablet per day with 4 to 8 oz. of water in the middle of or 30 minutes before meal.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28337976
The half-maximal proliferation inhibitory concentration (IC50) of crocin was determined to be 209 ± 5, 275 ± 8, 380 ± 7 and 660 ± 23 nM for HCC1806, HCC70, HeLa, and CCD1059sk cells, respectively
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:42:51 GMT 2023
by
admin
on
Sat Dec 16 10:42:51 GMT 2023
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Record UNII |
877GWI46C2
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Record Status |
Validated (UNII)
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Record Version |
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Crocin
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877GWI46C2
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877GWI46C2
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m3849
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DTXSID7046172
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5281233
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DB11874
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2262278
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